Apocynin is an aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Definition
Apocynin is an aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor and a plant metabolite. It is a member of acetophenones, a methyl ketone and an aromatic ketone.
Source: PubChem
US FDA substance register · UNII B6J7B9UDTR · registered name APOCYNIN · single chemical substance
Apocynin is the organic compound that conforms to the formula:
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 498-02-2
- EC No.EU chemical inventory number
- 207-854-5
- DTXSIDUS EPA chemical ID
- DTXSID7060097
- DTXCIDUS EPA compound ID
- DTXCID1040740
- IUPAC
- 1-(4-Hydroxy-3-methoxyphenyl)ethan-1-one
- Molecular formula
- C9H10O3
- Molecular weight
- 166.176 g/mol
Measured properties
- Appearance
- Light yellow to yellow solid
- Colour
- Light yellow to yellow solid
- Odour
- Faint vanilla odor
- Melting/freezing point
- 115 ℃
- Initial boiling point and range
- 297 ℃
- Water solubility
- 5000 ㎎/ℓ (20deg C)
- n-Octanol/water partition coefficient (Kow)
- 1.020
- Molecular weight
- 166.173
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance3
- Flavouring and nutrient1
Source: US EPA CompTox dashboard
Related literature
- Local apocynin improves acetylcholine- but not insulin-mediated vasodilation in the cutaneous microvasculature of women with a history of gestational diabetes · 2026
- Apocynin Induces Apoptosis in Human Lung Cancer A549 Cells via Regulating Apoptotic Protein and Inflammatory Cytokines · 2025
- Is the use of anthracyclines implicated in myocardial injury? Investigating the cardio modulatory effects of naringenin and apocynin in doxorubicin-induced cardiotoxicity in rats · 2025
- Natural treasures from Picrorhiza kurrooa: a computational exploration of drug-like properties and bioactivity of kutkin, cucurbitacin, apocynin and lupanine · 2024
- Injectable gelatin/oxidized dextran hydrogel loaded with apocynin for skin tissue regeneration. · 2021
Linked databases 16
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese