Are there usage precautions?

피부 미백, 여드름 치료 및 항염 효과로 유명한 성분입니다. 과다 색소 침착을 완화하고, 모공을 정화하며, 피부의 유분 균형을 맞춰줍니다. Azelaic acid inhibits the growth of C. acnes and prevents the buildup of keratin in hair follicles, which reduces comedones. It has anti-inflammatory effects and can improve skin tone by reducing hyperpigmentation

All ingredients

Ingredient Dictionary

AZELAIC ACID

Nonanedioic acid is an alpha,-dicarboxylic acid that is heptane substituted at positions 1 and 7 by carboxy groups.

How much products actually contain

No product states its amount yet.

Of the products containing it, 25 list it before the 1% line and 5 after it (usually 1% or less).

Products using this ingredient

12 of 30 confirmed · likeliest to carry enough first · See all 30

Definition

Nonanedioic acid is an alpha,-dicarboxylic acid that is heptane substituted at positions 1 and 7 by carboxy groups. It has a role as an antibacterial agent, an antineoplastic agent, a dermatologic drug and a plant metabolite. It is a dicarboxylic fatty acid and an alpha,omega-dicarboxylic acid. It is a conjugate acid of an azelaate and an azelaate(2-).

Source: PubChem

US FDA substance register · UNII F2VW3D43YT · registered name Azelaic acid · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps pH steadyBUFFERINGListed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCE

Safety & regulatory references

Banned: ASEAN · South Korea
Restricted or banned: Argentina · ASEAN · Brazil · South Korea

Source: ASEAN Cosmetic Directive · MFDS (Korea) cosmetic regulatory information

Canada

Maximum Concentration Permitted : 14%

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Dicarboxylic Acids, Salts and Esters

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name アゼライン酸: 本品は、次の化学式で表されるジカルボン酸である。

Source: JCIA labelling names (Japan)

Names & identifiers

AZELAIC ACIDINCI아젤라익애씨드Korean label name (MFDS standard)Nonanedioic acidSynonymAZELAIC ACID, ITS SALTS AND DERIVATIVESSynonymアゼライン酸Japanese labelling name

CAS No.chemical registry number: 123-99-9
EC No.EU chemical inventory number: 204-669-1
DTXSIDUS EPA chemical ID: DTXSID8021640
DTXCIDUS EPA compound ID: DTXCID501640

IUPAC: Nonanedioic acid
Molecular formula: C9H16O4
Molecular weight: 188.223 g/mol

Measured properties

Appearance: Dry Powder, Other Solid, Large Crystals · Yellowish to white solid, [HSDB] White flakes, [Acros Organics MSDS]
Boiling point: 286.5 °C at 1.00E+02 mm Hg · 357.1 °C, 287 °C at 100 mm Hg
Melting point: 106.5 °C · 160.5 °C
Solubility: 2400 mg/L (at 20 °C) · Slightly soluble in ethy ether, benzene, DMSO, soluble in ethanol
Density: 1.225 g/cu cm at 25 °C
Dissociation constant: 4.55 (at 25 °C) · pKa = 4.55
Melting/freezing point: 107 ℃
Initial boiling point and range: 287 ℃(at 100 mmHg)
Flash point: 192 ℃
Upper/lower flammability or explosive limits: 6.5 / 0.9 %
Vapour pressure: (1.07E-008 mmHg at 25C)
Water solubility: (2.4 g/L at 20 C)
Relative density: 1.029
n-Octanol/water partition coefficient (Kow): 1.33
Viscosity: 5.50 cP (150 C)
Molecular weight: 188.22

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 13 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

pH regulating agent3
Deodorizer2
Plasticizer2
Processing aids not otherwise specified2
Fragrance1
Flavouring and nutrient1
Monomers1
Lubricating agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 1 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Ambiguous
skin irritation: in vivo · Screening · other guideline: OECD Guideline 406 (Skin Sensitisation) equivalent or similar to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Category 6.4A (Category 2A)
Eye Irritation · Read Across