Ingredient Dictionary

BARBITURIC ACID

Barbituric acid is a barbiturate, the structure of which is that of perhydropyrimidine substituted at C-2, -4 and -6 by oxo groups.

Definition

Barbituric acid is a barbiturate, the structure of which is that of perhydropyrimidine substituted at C-2, -4 and -6 by oxo groups. Barbituric acid is the parent compound of barbiturate drugs, although it is not itself pharmacologically active. It has a role as a xenobiotic and an allergen. It is a conjugate acid of a barbiturate, a barbiturate(2-) and a barbiturate(1-).

Source: PubChem

US FDA substance register · UNII WQ92Y2793G · registered name Barbituric acid · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Barbituric Acid is the organic compound that conforms to the formula:

Cosmetic roles

Makes skin soft and smoothSKIN CONDITIONING - EMOLLIENT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

BARBITURIC ACIDINCI2,4,6(1H,3H,5H)-PyrimidinetrioneSynonym

CAS No.chemical registry number: 67-52-7
EC No.EU chemical inventory number: 200-658-0
DTXSIDUS EPA chemical ID: DTXSID8020129
DTXCIDUS EPA compound ID: DTXCID20129

IUPAC: 1,3-Diazinane-2,4,6-trione
Molecular formula: C4H4N2O3
Molecular weight: 128.087 g/mol

Measured properties

Appearance: solid
Colour: white
pH: 2~3 (50 g/ℓ, 60℃)
Initial boiling point and range: 260 ℃
Flash point: 150 ℃
Flammability (solid, gas): not flammable
Vapour pressure: 0 ㎜Hg (25℃)
Water solubility: 11.45 g/ℓ (25℃)
Vapour density: 720 ㎏/㎥
Relative density: 1.455 (g/cm3)
n-Octanol/water partition coefficient (Kow): -1.47 (log Pow)
Auto-ignition temperature: ≥260 ℃
Decomposition temperature: ≥ 260 ℃
Molecular weight: 128.09

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Intermediate2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 3 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 5 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across