Ingredient Dictionary

BASIC GREEN 4

Malachite green is an organic chloride salt that is the monochloride salt of malachite green cation.

Definition

Malachite green is an organic chloride salt that is the monochloride salt of malachite green cation. Used as a green-coloured dye, as a counter-stain in histology, and for its anti-fungal properties in aquaculture. It has a role as an antibacterial agent, a carcinogenic agent, a teratogenic agent, a fluorochrome, a histological dye, an environmental contaminant and an antifungal drug. It contains a malachite green cation.

Source: PubChem

US FDA substance register · UNII 12058M7ORO · registered name MALACHITE GREEN · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Korea’s toxic-substance GHS classification: Danger · H301 (category 3) · H318 (category 1) · H361 (category 2) · +2 more

Source: Korea toxic substances GHS register (NIER)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction II/1188

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name 塩基性緑４: 本品は、次の化学式で表されるトリフェニルメタン系色素である。

Source: JCIA labelling names (Japan)

Names & identifiers

BASIC GREEN 4INCI염기성녹색4호Korean label name (MFDS standard)Methanaminium, N-[4-[[4-(dimethylamino)phenyl]phenylmethylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chlorideSynonym塩基性緑４Japanese labelling name

CAS No.chemical registry number: 569-64-2
EC No.EU chemical inventory number: 209-322-8
DTXSIDUS EPA chemical ID: DTXSID1025512
DTXCIDUS EPA compound ID: DTXCID605512

IUPAC: 4-{[4-(Dimethylamino)phenyl](phenyl)methylidene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium chloride
Molecular formula: C23H25ClN2
Molecular weight: 364.92 g/mol

Measured properties

Appearance: C.i. basic green 4 appears as green crystals with metallic luster. Water solutions are blue-green. Used in dyeing silk, wool, biological staining, etc. · Wet Solid, Liquid
Solubility: Sol in alcohol, methanol, amyl alcohol · Sol 1 /part/ in 15 /parts/ of water and 1 /part/ in 15 /parts/ of alcohol.
pH: 1% sol in water has a pH of 1.4 · 1.4
Vapour pressure: 0.00000000000024 ㎜Hg(at 25 °C)
Water solubility: 40000 ㎎/ℓ(at 25℃)
n-Octanol/water partition coefficient (Kow): 0.62
Molecular weight: 364.91

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Dye3

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 3 eye studies are on record.

Classed as moderate2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

Classification not possible
Skin Irritation · Screening
Category 6.3A (Category 2)
Skin Irritation · Read Across
Classification not possible
Skin Sensitization · Screening
Category 8.3A (Category 1)
Eye Irritation · Read Across
Eye Dam. 1
Eye Irritation · Authoritative
Category 1
Eye Irritation · Screening