Docosan-1-ol is a long-chain primary fatty alcohol that is docosane substituted by a hydroxy group at position 1.
How much products actually contain
No product states its amount yet.
Of the products containing it, 598 list it before the 1% line and 196 after it (usually 1% or less).
Products using this ingredient
12 of 787 confirmed · likeliest to carry enough first · See all 787
Summer FridaysSummer Fridays Light Aura Vitamin C + Peptide Eye Cream
Dr. SquatchDr. Squatch Cool Fresh Aloe Conditioner
Dr. SquatchDr. Squatch Pine Tar Conditioner
Dr. SquatchDr. Squatch Summer Citrus Conditioner
Dr. SquatchDr. Squatch Wood Barrel Bourbon Conditioner
DermalogicaDermalogica hydro masque exfoliant
TSUBAKIPremium Volume & Repair Treatment 160g
Manyo FactoryManyo Factory Panthetoin Enriched Balm
MEDIPEELMEDIPEEL Peptide Tox Bor Cream 50g
Supergoop!Supergoop! PLAY Mineral Lotion SPF 30
BubbleBubble Soft Launch
Dr. SquatchDr. Squatch Coconut Castaway Conditioner
Definition
Docosan-1-ol is a long-chain primary fatty alcohol that is docosane substituted by a hydroxy group at position 1. It is a non-prescription medicine approved by the FDA to shorten healing time of cold sores. It has a role as an antiviral drug and a plant metabolite. It is a docosanol and a long-chain primary fatty alcohol.
Source: PubChem
US FDA substance register · UNII 9G1OE216XY · registered name Docosanol · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2005/2006
Reviewed by CIR: Final Report on the Safety Assessment of Cetearyl Alcohol, Cetyl Alcohol, Isostearyl Alcohol, Myristyl Alcohol, and Behenyl Alcohol
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ベヘニルアルコール: 本品は、次の化学式で表される脂肪族アルコールである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 661-19-8
- EC No.EU chemical inventory number
- 211-546-6
- DTXSIDUS EPA chemical ID
- DTXSID4027286
- DTXCIDUS EPA compound ID
- DTXCID907286
- IUPAC
- Docosan-1-ol
- Molecular formula
- C22H46O
- Molecular weight
- 326.609 g/mol
Measured properties
- Appearance
- Other Solid, Large Crystals, Liquid · Colorless waxy solid, [HSDB] Powder, [MSDSonline]
- Boiling point
- 180 °C at 0.22 mm Hg
- Melting point
- 65-72 °C · 72.5 °C
- Solubility
- Slightly soluble in ether, very soluble in ethanol, methanol, petroleum ether, soluble in chloroform · Insoluble in water
- Density
- 0.8063 g/ml at 75 °C, 0.7986 g/ml at 85 °C, 0.7911 g/ml at 95 °C
- Colour
- colourless
- Melting/freezing point
- 72.5 ℃
- Initial boiling point and range
- 180 ℃(at 0.22 mm Hg)
- Flash point
- 210 ℃(closed cup)
- Vapour pressure
- 0.000000061 ㎜Hg
- Water solubility
- (7.5E-005mg/L(25℃), est.)
- Vapour density
- 11.3
- Relative density
- 0.8063 (at 75 ℃)
- n-Octanol/water partition coefficient (Kow)
- 9.68
- Molecular weight
- 326.6
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 32 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner8
- Solvent6
- Emulsifier4
- Binder3
- Viscosity modifier3
- Thickening agent1
- Plasticizer1
- Processing aids not otherwise specified1
5 other uses
- Monomers1
- Dispersing agent1
- Defoamer1
- Stabilizing agent1
- Fragrance1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
- Enhancement of the Gel Hardness of Candelilla Wax through the Addition of Long-chain Ester Wax Behenyl Behenate. · 2022
- The Effect of Vegetable Oil Composition on the Structural Properties of Oleogels Based on Behenyl Alcohol/Behenic Acid Oleogelator System. · 2021
- Alkyl polyglucoside-based emulsions as vehicles for topical spironolactone: A textural analysis · 2021
- Effect of the ratio between behenyl alcohol and behenic acid on the oleogel properties. · 2019
- Preparation of Liquid Crystal Emulsion for Transdermal Delivery of Glycyrrhizic Acid and Physical Characteristics and In Vitro Skin Permeation Studies · 2015
Linked databases 20
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese