1H-benzimidazole is the 1H-tautomer of benzimidazole.
Definition
1H-benzimidazole is the 1H-tautomer of benzimidazole. It is a benzimidazole and a polycyclic heteroarene. It is a conjugate acid of a benzimidazolide. It is a tautomer of a 4H-benzimidazole, a 2H-benzimidazole and a 3aH-benzimidazole.
Source: PubChem
US FDA substance register · UNII E24GX49LD8 · registered name BENZIMIDAZOLE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ベンズイミダゾール: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 51-17-2
- EC No.EU chemical inventory number
- 200-081-4
- EC No.EU chemical inventory number
- 200-181-4
- DTXSIDUS EPA chemical ID
- DTXSID8024573
- DTXCIDUS EPA compound ID
- DTXCID704573
- IUPAC
- 1H-1,3-Benzimidazole
- Molecular formula
- C7H6N2
- Molecular weight
- 118.139 g/mol
Measured properties
- Appearance
- solid
- Melting/freezing point
- 170.5 ℃
- Initial boiling point and range
- &, gt, 360 ℃
- Vapour pressure
- 0.0000764 ㎜Hg (25 ℃)
- Water solubility
- 2010 ㎎/ℓ (Water Solubility 20 ℃)
- n-Octanol/water partition coefficient (Kow)
- 1.32
- Molecular weight
- 118.14
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Pigment2
- Dye1
- No specific technical function1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Draize method equivalent or similar to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: as mentioned below equivalent or similar to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: as mentioned below equivalent or similar to
Source: US EPA CompTox dashboard
Related literature
- From Scaffold to Therapy: Benzimidazole Pharmacophore Evolution in Breast Cancer Research. · 2026
- Impact of Heterocyclic Benzimidazole–Thioether Derivatives on the Proliferation of Human Dermal Fibroblast · 2025
- Benzimidazole‐Containing Compounds as Anticancer Agents · 2024
- Synthesis of 2-Substituted Benzimidazole Derivatives as a Platform for the Development of UV Filters and Radical Scavengers in Sunscreens · 2023
- In silico designing of some Benzimidazole derivatives for Anti-fungal activity · 2021
Linked databases 19
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese