Ingredient Dictionary

BENZISOTHIAZOLINONE

Definition

Benzo[d]isothiazol-3-one is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. It has a role as a sensitiser, a xenobiotic, a disinfectant, a platelet aggregation inhibitor, an environmental contaminant and a drug allergen. It is an organic heterobicyclic compound and an organonitrogen heterocyclic compound.

Source: PubChem

US FDA substance register · UNII HRA0F1A4R3 · registered name Benzisothiazolinone · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Inhibits microbial growthANTIMICROBIAL

Safety & regulatory references

Korea’s toxic-substance GHS classification: Danger · H410 (category 1) · H400 (category 1) · H315 (category 2) · +4 more

Source: Korea toxic substances GHS register (NIER)

SCCS opinion: Opinion on Benzisothiazolinone; Opinion on Benzisothiazolinone P96

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

BENZISOTHIAZOLINONEINCI1,2-Benzisothiazol-3(2H)-oneSynonym

CAS No.chemical registry number: 2634-33-5
EC No.EU chemical inventory number: 220-120-9
DTXSIDUS EPA chemical ID: DTXSID5032523
DTXCIDUS EPA compound ID: DTXCID3012523

IUPAC: 1,2-Benzothiazol-3(2H)-one
Molecular formula: C7H5NOS
Molecular weight: 151.18 g/mol

Measured properties

Appearance: CBI · Solid
Boiling point: 327.6 °C
Melting point: 156.6 °C · 157 - 158 °C
Solubility: In water, 1.1 g/L at 20 °C, 0.938 g/L at 20 °C and pH 4.8, 1.288 g/L at 20 deg and pH 6.7, 1.651 g/L at 20 °C at pH 9.1, 1.198 g/L at 30 °C pH 4.8 · 21.7 [ug/mL] (The mean of the results at pH 7.4)
Density: 1.483 g/cu cm at 20 °C
Stability: Stable under recommended storage conditions.
Melting/freezing point: 159.5~160 ℃
Initial boiling point and range: 327.6 ℃
Vapour pressure: 0.0000257 ㎜Hg (25℃ (est.))
n-Octanol/water partition coefficient (Kow): 0.64 (est.)
Molecular weight: 151.9

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 514 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Preservative451
Biocide35
Processing aids not otherwise specified10
Stabilizing agent4
Antioxidant2
Binder2
Degradant/impurity (EPA)2
Fragrance2

5 other uses

Sealant (barrier)2
Adhesion/cohesion promoter1
Soil amendments1
Anti-adhesive/cohesive1
Defoamer1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

11 skin studies and 4 eye studies are on record.

Classed as moderate2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 15 studies

Category 1A
Skin Sensitization · Screening
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Skin sensitization - Category 1
Skin Sensitization · Screening
Category 6.3B (Category 3)
Skin Irritation · Read Across
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Sh
Skin Sensitization · Authoritative
Category 6.3A (Category 2)
Skin Irritation · Read Across
Skin corrosion/irritation - Category 2
Skin Irritation · Screening
Skin Irrit. 2
Skin Irritation · Authoritative
Skin Sens. 1
Skin Sensitization · Authoritative
Category 2
Skin Irritation · Screening
Category 1
Eye Irritation · Screening
Serious eye damage/eye irritation - Category 1
Eye Irritation · Screening
Category 8.3A (Category 1)
Eye Irritation · Read Across
Eye Dam. 1
Eye Irritation · Authoritative