What is this ingredient?

미국 FDA 물질 등록 · UNII 73P3618V2E · 등록명 OCTABENZONE · 단일 화학물질

All ingredients

Ingredient Dictionary

BENZOPHENONE-12

Octabenzone is a member of benzophenones.

Definition

US FDA substance register · UNII 73P3618V2E · registered name OCTABENZONE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Octabenzone is a member of benzophenones.

Source: PubChem

Cosmetic roles

Absorbs UV (including to protect the product)UV ABSORBER

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: Final Report: Amended Safety Assessment of Benzophenones as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name オキシベンゾン－１２: 本品は、次の化学式で表されるベンゾフェノン誘導体である。

Source: JCIA labelling names (Japan)

Names & identifiers

BENZOPHENONE-12INCI벤조페논-12Korean label name (MFDS standard)Methanone, [2-hydroxy-4-(octyloxy)phenyl]phenyl-Synonymオキシベンゾン－１２Japanese labelling name

CAS No.chemical registry number: 1843-05-6
EC No.EU chemical inventory number: 217-421-2
DTXSIDUS EPA chemical ID: DTXSID9027441
DTXCIDUS EPA compound ID: DTXCID107441

IUPAC: [2-Hydroxy-4-(octyloxy)phenyl](phenyl)methanone
Molecular formula: C21H26O3
Molecular weight: 326.436 g/mol

Measured properties

Melting/freezing point: 45~49 ℃
Vapour pressure: 0.0000000692 ㎜Hg (at 25C(est.))
Water solubility: 0.175 ㎎/ℓ (at 25C(est.))
Relative density: 1.16 ()
n-Octanol/water partition coefficient (Kow): 6.96 ((est.))
Decomposition temperature: (&amp, gt, 300C)
Molecular weight: 326.44

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 241 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Stabilizing agent158
UV stabilizer75
Heat stabilizer2
Photosensitive agent2
Antioxidant2
Processing aids not otherwise specified1
Fragrance1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 2 eye studies are on record.

Classed as moderate2Classed as low3

The studies disagree (the most common conclusion covers 40%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

Low to Moderate Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) 1981 followed, reliability scoring based on 1992 guideline according to EU Method B.6 (Skin Sensitisation) 84/449/EEC
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) -reliability scoring based on 2002 guideline equivalent or similar to EPA OPP 81-5 (Acute Dermal Irritation) according to
Low to Moderate Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation)
SkinIrr2
Skin Irritation · QSAR Predicted
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to