2,2'-Dihydroxy-4-methoxybenzophenone is a member of benzophenones.
- Korean limit
- 3%
Definition
2,2'-Dihydroxy-4-methoxybenzophenone is a member of benzophenones.
Source: PubChem
US FDA substance register · UNII B762XZ551X · registered name DIOXYBENZONE · single chemical substance
Cosmetic roles
Safety & regulatory references
Argentina · Brazil
- Maximum concentration permitted at final product : 3%
Canada
- Maximum Concentration Permitted : ≤ 3%
United States
- Specific Limitations and Comments : Use of the term "sunscreen" or similar sun protection wording in a product's labeling generally causes the product to be subject to regulation as a drug or a drug/cosmetic, depending on the claims. However, sunscreen ingredients may also be used in some cosmetic products to protect the products’ color. The labelling must also state why the sunscreen ingredient is used, for example, "Contains a sunscreen to protect product color." If this explanation isn’t present, the product may be subject to regulation as a drug (21 CFR 700.35). For more information on sunscreens, refer to Tanning Products
South Korea
- Maximum concentration : 3%
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2002/2003
Reviewed by CIR: Final Report: Amended Safety Assessment of Benzophenones as Used in Cosmetics
Reviewed by CIR: Addendum to the Final Report on the Safety Assessment of Benzophenones-1, -3, -4, -5, .-9, and -11 to Include Benzophenones-2, -6, and -8 (JACT 2(5): 35-77, 1983.)
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 131-53-3
- EC No.EU chemical inventory number
- 205-026-8
- DTXSIDUS EPA chemical ID
- DTXSID3022403
- DTXCIDUS EPA compound ID
- DTXCID202403
- IUPAC
- (2-Hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone
- Molecular formula
- C14H12O4
- Molecular weight
- 244.246 g/mol
Measured properties
- Appearance
- 2,2'-dihydroxy-4-methoxybenzophenone is a yellow powder. (NTP, 1992) · Dry Powder
- Boiling point
- 338 to 347 °F at 1 mmHg (NTP, 1992) · 172.5
- Melting point
- 74 · 68 °C
- Solubility
- Practically insoluble in water · Solubility in g/100 mL at 25 °C: ethanol 21.8, isopropanol 17, propylene glycol6.2, ethylene glycol 3.0, n-hexane 1.5
- Density
- 1.39 g/cu cm at 22.7 °C
- Stability
- Stable under recommended storage conditions.
- Melting/freezing point
- 68 ℃
- Initial boiling point and range
- 172 ℃
- Flash point
- 146 ℃
- Vapour pressure
- 0.0000657 ㎜Hg
- Water solubility
- 52.73 ㎎/ℓ
- n-Octanol/water partition coefficient (Kow)
- 3.82
- Molecular weight
- 244.25
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 8 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- UV stabilizer7
- Processing aids not otherwise specified1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) July 2013 according to
Source: US EPA CompTox dashboard
Related literature
- Biomonitoring of benzophenones in guano samples of wild bats in Poland · 2024
- Mutagenicity evaluation to UV filters of benzophenone-6, benzophenone-8, and 4-methylbenzylidene camphor by Ames test · 2021
- Benzophenone-3 and benzophenone-8 exhibit obesogenic activity via peroxisome proliferator-activated receptor γ pathway. · 2020
- Risk assessment of benzophenone-8 in cosmetic products · 2017
Linked databases 21
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese