Benzophenone can cause cancer according to California Labor Code.
Definition
US FDA substance register · UNII 701M4TTV9O · registered name Benzophenone · single chemical substance
Benzophenone can cause cancer according to California Labor Code.
Source: PubChem
Benzophenone is the organic compound that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Banned
- ASEAN · European Union · United Kingdom
- Restricted or banned
- ASEAN · 유럽
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · UK cosmetics regulations (OPSS) · MFDS (Korea) cosmetic regulatory information
Canada
- Maximum Concentration Permitted : 3%
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex II (prohibited substances), entry 1703
Restriction II/1703
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ベンゾフェノン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 119-61-9
- EC No.EU chemical inventory number
- 204-337-6
- DTXSIDUS EPA chemical ID
- DTXSID0021961
- DTXCIDUS EPA compound ID
- DTXCID101961
- IUPAC
- Diphenylmethanone
- Molecular formula
- C13H10O
- Molecular weight
- 182.222 g/mol
Measured properties
- Appearance
- Benzophenone appears as white solid with a flowery odor. May float or sink in water. (USCG, 1999) · Dry Powder, Liquid, Large Crystals
- Odour
- Geranium-like odor · Sweet, rose-like odor
- Boiling point
- 582.6 °F at 760 mmHg (NTP, 1992) · 305.4 °C
- Melting point
- alpha-118.6 °F, beta-79 °F, gamma-117 °F. (NTP, 1992) · 47.8 °C
- Solubility
- Insoluble (<1 mg/ml at 77 °F) (NTP, 1992) · 137 mg/L (at 25 °C)
- Density
- 1.085 at 122 °F (USCG, 1999) - Denser than water, will sink · 1.111 g/cu cm at 18 °C
- Melting/freezing point
- 49~51 ℃
- Initial boiling point and range
- 305 ℃
- Flash point
- &, gt, 110 ℃
- Vapour pressure
- 0.00193 ㎜Hg (at 25C(est.))
- Water solubility
- 137 ㎎/ℓ (at 25C)
- Vapour density
- 6.3 ()
- Relative density
- 1.1108 ()
- n-Octanol/water partition coefficient (Kow)
- 3.18
- Viscosity
- 13.61 cP (25 C)
- Molecular weight
- 182.23
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 52 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Photosensitizers21
- Fragrance7
- UV stabilizer6
- Flavouring and nutrient2
- Processing aids not otherwise specified2
- Chemical reaction regulator2
- Semiconductor and photovoltaic agent2
- Intermediate2
5 other uses
- Stabilizing agent2
- Deodorizer2
- Photosensitive agent2
- Anti-stain agent1
- No specific technical function1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
6 skin studies and 1 eye studies are on record.
The studies disagree (the most common conclusion covers 17%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 7 studies
- Classification not possible
Skin Irritation · Screening - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) Magnusson & Kligman (1970) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) Maximisation test - Not classified
Skin Sensitization · Screening - Moderate or Mild Irritation
skin irritation: in vivo · Screening · other guideline: Draize method 1944 no guideline followed - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - Category 2B
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Benzophenone-3 promotion of mammary tumorigenesis is diet-dependent · 2020
- Is the commonly used UV filter benzophenone-3 a risk factor for the nervous system? · 2021
- A comparative study of the in vitro dermal absorption of radiolabeled benzophenone through human skin. · 2024
- Benzophenone Accumulates over Time from the Degradation of Octocrylene in Commercial Sunscreen Products. · 2021
- Interactions between benzophenone-3 and dietary fat in mammary tumorigenesis · 2020
Linked databases 28
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- Health Canada Cosmetic Ingredient Hotlist
- IARC carcinogen classification
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese