Benzoyl peroxide is a carbonyl compound.
Definition
Benzoyl peroxide is a carbonyl compound.
Source: PubChem
US FDA substance register · UNII W9WZN9A0GM · registered name Benzoyl peroxide · single chemical substance
Cosmetic roles
Points to consider
FDA-approved for acne treatment at concentrations between 2.5% and 10%. Considered safe for topical use. Possible side effects include dryness, redness, peeling, or mild irritation, especially when used in higher concentrations or combined with other potent actives.
Usage reference
Benzoyl Peroxide works by releasing oxygen free radicals, which kill Cutibacterium acnes (formerly Propionibacterium acnes), the bacteria responsible for acne. It also helps to exfoliate dead skin cells and reduce comedones by promoting skin cell turnover, which prevents clogged pores.
Safety & regulatory references
- Restricted or banned
- Argentina · Brazil · China · South Korea
- Restricted
- United Kingdom
Source: MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · UK cosmetics regulations (OPSS)
ASEAN
- Field of application and/or use : Artificial nail systems
- Maximum authorised concentration in the finished cosmetic product : 0.7 % (After mixing for use)
- Other limitations and requirements : Professional use only
- Conditions of use and warning which must be printed on the labels : • For professional use only • Avoid skin contact • Read directions for use carefully
Canada
- Conditions of Use by product type : (a) Not permitted in products to be applied to the skin. (b) Products to be applied to the fingernails or in hair dyes
- Maximum Concentration Permitted : b) 10% as a catalyst
European Union
- Product Type, body parts : Artificial nail systems
- Maximum concentration in ready for use preparation : 0.7% (after mixing for use)
- Other : Professional use
- Wording of conditions of use and warnings : For professional use only Avoid skin contact Read directions for use carefully
Source: MFDS (Korea) cosmetic regulatory information
Korea’s toxic-substance GHS classification: Danger · H241 (category 2) · H319 (category 2) · H400 (category 1) · +1 more
EU Cosmetics Regulation, Annex III (restricted substances), entry 94 · maximum concentration 0.7% (after mixing for use) · applies to Artificial nail systems
Restriction III/94
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name 過酸化ベンゾイル: 本品は、次の化学式で表される過酸化物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 94-36-0
- EC No.EU chemical inventory number
- 202-327-6
- DTXSIDUS EPA chemical ID
- DTXSID6024591
- DTXCIDUS EPA compound ID
- DTXCID001072
- Molecular formula
- C14H10O4
- Molecular weight
- 242.23 g/mol
Measured properties
- Appearance
- Benzoyl peroxide appears as odorless white powder or granules. Sinks in water. (USCG, 1999) · Liquid, CBI, Dry Powder, Wet Solid
- Odour
- Faint, benzaldehyde-like odor.
- Boiling point
- Decomposes explosively (NTP, 1992) · Decomposes explosively above melting point. Does not reach boiling point.
- Melting point
- 217 to 221 °F (decomposes) (NTP, 1992) · 103 - 106
- Solubility
- less than 1 mg/mL at 79 °F (NTP, 1992) · <1%
- Density
- 1.334 at 59 °F (USCG, 1999) - Denser than water, will sink · 1.3340 at 25 °C
- Melting/freezing point
- 103~106 ℃
- Flash point
- 176 ℉
- Vapour pressure
- 0.1 (torr, at 20℃)
- Water solubility
- 9.1 ㎎/ℓ (at 25℃)
- Vapour density
- 8.4
- Relative density
- 1.334 (at 25℃)
- n-Octanol/water partition coefficient (Kow)
- 3.46
- Auto-ignition temperature
- 80 ℃
- Decomposition temperature
- 1551.7 (kcal/mole)
- Molecular weight
- 242.24
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 81 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Catalyst40
- Chemical reaction regulator13
- Hardener10
- Oxidizing agent3
- Processing aids not otherwise specified3
- Adhesion/cohesion promoter2
- Pharmaceutical (EPA)1
- Dye1
8 other uses
- Food preservative (EPA)1
- Sealant (barrier)1
- Intermediate1
- Stabilizing agent1
- Filler1
- Plasticizer1
- Elasticizer1
- Polymerization promoter1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
8 skin studies and 6 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 14 studies
- Not classified
Skin Irritation · Screening - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Category 1
Skin Sensitization · Screening - Skin Sens. 1
Skin Sensitization · Screening - Skin Sens. 1
Skin Sensitization · Authoritative - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Eye Irrit. 2
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Category 2
Eye Irritation · Screening - Eye Irrit. 2
Eye Irritation · Authoritative - Moderate or Mild Irritation
eye irritation: in vivo · Screening · other guideline: US FDA, 21 CFR, Part 191, Hazardous substances test for eye irritants according to
Source: US EPA CompTox dashboard
Related literature
- Real-World Adverse Events Associated with Encapsulated Benzoyl Peroxide/Tretinoin, 3%/0.1%, and Encapsulated Benzoyl Peroxide, 5% · 2024
- benzoyl peroxide · 2020
- The evolution of benzoyl peroxide therapy. · 2008
- The Efficacy and Safely of a Combination Benzoyl Peroxide/Clindamycin Topical Gel Compared with Benzoyl Peroxide Alone and a Benzoyl Peroxide/Erythromycin Combination Product · 2001
- Topical and bioavailability of benzoyl peroxide · 1985
Linked databases 24
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- Health Canada Cosmetic Ingredient Hotlist
- IARC carcinogen classification
- JCIA labelling names (Japan)
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese