Benzoyl peroxide is a carbonyl compound.
定义
Benzoyl peroxide is a carbonyl compound.
来源: PubChem
美国FDA 物质登记 · UNII W9WZN9A0GM · 登记名称 Benzoyl peroxide · 单一化学物质
化妆品中的作用
可能需要注意
FDA-approved for acne treatment at concentrations between 2.5% and 10%. Considered safe for topical use. Possible side effects include dryness, redness, peeling, or mild irritation, especially when used in higher concentrations or combined with other potent actives.
使用参考
Benzoyl Peroxide works by releasing oxygen free radicals, which kill Cutibacterium acnes (formerly Propionibacterium acnes), the bacteria responsible for acne. It also helps to exfoliate dead skin cells and reduce comedones by promoting skin cell turnover, which prevents clogged pores.
安全与法规参考
- 限用·禁用
- 阿根廷 · 巴西 · 韩国 · 中国
- 限用
- 英国
来源: 韩国食药处 化妆品法规信息 · 东盟化妆品指令 · 欧盟化妆品法规 · 加拿大禁用·限用成分清单 · 英国化妆品法规
东盟
- Field of application and/or use : Artificial nail systems
- Maximum authorised concentration in the finished cosmetic product : 0.7 % (After mixing for use)
- Other limitations and requirements : Professional use only
- Conditions of use and warning which must be printed on the labels : • For professional use only • Avoid skin contact • Read directions for use carefully
加拿大
- Conditions of Use by product type : (a) Not permitted in products to be applied to the skin. (b) Products to be applied to the fingernails or in hair dyes
- Maximum Concentration Permitted : b) 10% as a catalyst
欧盟
- Product Type, body parts : Artificial nail systems
- Maximum concentration in ready for use preparation : 0.7% (after mixing for use)
- Other : Professional use
- Wording of conditions of use and warnings : For professional use only Avoid skin contact Read directions for use carefully
来源: 韩国食药处 化妆品法规信息
韩国有毒物质 GHS 分类: 危险 · H241 (第2类) · H319 (第2类) · H400 (第1类) · 另有 1 项
欧盟化妆品法规 附录III(限用物质) 第94项 · 最高浓度 0.7% (after mixing for use) · 适用 Artificial nail systems
来源: 欧盟限用成分(附录III)
Restriction III/94
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 過酸化ベンゾイル: 本品は、次の化学式で表される過酸化物である。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
- CAS No.化学物质登记号
- 94-36-0
- EC No.欧盟化学品目录编号
- 202-327-6
- DTXSID美国EPA化学品编号
- DTXSID6024591
- DTXCID美国EPA化合物编号
- DTXCID001072
- 分子式
- C14H10O4
- 分子量
- 242.23 g/mol
实测物性
- 性状
- Benzoyl peroxide appears as odorless white powder or granules. Sinks in water. (USCG, 1999) · Liquid, CBI, Dry Powder, Wet Solid
- 气味
- Faint, benzaldehyde-like odor.
- 沸点
- Decomposes explosively (NTP, 1992) · Decomposes explosively above melting point. Does not reach boiling point.
- 熔点
- 217 to 221 °F (decomposes) (NTP, 1992) · 103 - 106
- 溶解性
- less than 1 mg/mL at 79 °F (NTP, 1992) · <1%
- 密度
- 1.334 at 59 °F (USCG, 1999) - Denser than water, will sink · 1.3340 at 25 °C
- 熔点/凝固点
- 103~106 ℃
- 闪点
- 176 ℉
- 蒸气压
- 0.1 (torr, at 20℃)
- 溶解度
- 9.1 ㎎/ℓ (at 25℃)
- 蒸气密度
- 8.4
- 比重
- 1.334 (at 25℃)
- 正辛醇/水分配系数(Kow)
- 3.46
- 自燃温度
- 80 ℃
- 分解温度
- 1551.7 (kcal/mole)
- 分子量
- 242.24
这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 81 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。
- Catalyst40
- Chemical reaction regulator13
- Hardener10
- Oxidizing agent3
- Processing aids not otherwise specified3
- Adhesion/cohesion promoter2
- Pharmaceutical (EPA)1
- Dye1
其余用途 8 项
- Food preservative (EPA)1
- Sealant (barrier)1
- Intermediate1
- Stabilizing agent1
- Filler1
- Plasticizer1
- Elasticizer1
- Polymerization promoter1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 8 项、眼部试验 6 项。
试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 14 项试验
- Not classified
Skin Irritation · Screening - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Category 1
Skin Sensitization · Screening - Skin Sens. 1
Skin Sensitization · Screening - Skin Sens. 1
Skin Sensitization · Authoritative - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Eye Irrit. 2
Eye Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Category 2
Eye Irritation · Screening - Eye Irrit. 2
Eye Irritation · Authoritative - Moderate or Mild Irritation
eye irritation: in vivo · Screening · other guideline: US FDA, 21 CFR, Part 191, Hazardous substances test for eye irritants according to
来源: 美国EPA CompTox
相关文献
- Real-World Adverse Events Associated with Encapsulated Benzoyl Peroxide/Tretinoin, 3%/0.1%, and Encapsulated Benzoyl Peroxide, 5% · 2024
- benzoyl peroxide · 2020
- The evolution of benzoyl peroxide therapy. · 2008
- The Efficacy and Safely of a Combination Benzoyl Peroxide/Clindamycin Topical Gel Compared with Benzoyl Peroxide Alone and a Benzoyl Peroxide/Erythromycin Combination Product · 2001
- Topical and bioavailability of benzoyl peroxide · 1985
关联数据库 24
- 澳大利亚工业化学品名录(AICIS)
- 东盟化妆品指令
- 韩国安全保健公团 安全数据表
- 韩国食药处 化妆品法规信息 2 3 4
- 韩国有毒物质 GHS 信息(环境公团)
- 加拿大禁用·限用成分清单
- 美国EPA 化学品数据库(DSSTox)
- 美国EPA CompTox 2
- 美国FDA 物质登记(GSRS)
- 美国FDA 物质识别码(UNII)
- 欧盟 CosIng 成分清单 2
- 欧盟化妆品法规
- 欧盟限用成分(附录III)
- 日本化妆品工业联合会标示名称
- 英国化妆品法规
- ChEBI
- ChEMBL
- IARC 致癌性分类
- NIST 化学网络手册
- PubChem 2
- Tlooto 学术文献检索 2 3 4 5
- UniChem 化学物质统一 ID
- Wikidata
- Wikipedia · 英语 · 日语 · 中文