Benzyl nicotinate is a benzyl ester resulting from the formal condensation of the carboxy group of nicotinic acid with benzyl alcohol.
How much products actually contain
No product states its amount yet.
Of the products containing it, 3 list it before the 1% line and 0 after it (usually 1% or less).
Products using this ingredient
3 of 3 confirmed · likeliest to carry enough first
Definition
Benzyl nicotinate is a benzyl ester resulting from the formal condensation of the carboxy group of nicotinic acid with benzyl alcohol. It has been used as a rubefacient. It has a role as a vasodilator agent. It is functionally related to a nicotinic acid.
Source: PubChem
US FDA substance register · UNII S497LCF9C9 · registered name BENZYL NICOTINATE · single chemical substance
Cosmetic roles
Safety & regulatory references
Japan
- Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 0.2 g
- Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.2 g
- Maximum amount per 100 g (Cosmetics that may be used for mucosa) :
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ニコチン酸ベンジル: 本品は、ナイアシン（＊）とベンジルアルコール（＊）のエステルであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 94-44-0
- EC No.EU chemical inventory number
- 202-332-3
- DTXSIDUS EPA chemical ID
- DTXSID7046542
- DTXCIDUS EPA compound ID
- DTXCID5026542
- IUPAC
- Benzyl pyridine-3-carboxylate
- Molecular formula
- C13H11NO2
- Molecular weight
- 213.236 g/mol
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner3
- Anti-static agent2
- Pharmaceutical (EPA)1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- SkinSens1
Skin Sensitization · QSAR Predicted - Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- A Multicentric, Prospective, Observational, Single-Arm Registry Study to Assess the Clinical Safety and Effectiveness of Thrombophob Ointment (Heparin Sodium + Benzyl Nicotinate) in Indian Patients With Thrombophlebitis · 2024
- Innovative UPLC technique for concurrent quantification of etofenamate and benzyl nicotinate in the presence of methylparaben and benzyl alcohol in their topical cream: Greens, white, and Six Sigma methodologies. · 2024
- Simultaneous Determination of General Active Ingredients in Topical Formulations by Gas Chromatography with Flame Ionization Detection (GC-FID). · 2023
- Evaluation of chemotherapy infusion and phlebitis among cancer patients: A prospective observational single-center study · 2023
- Influence of nanosized delivery systems with benzyl nicotinate and penetration enhancers on skin oxygenation. · 2008
Linked databases 17
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata