Ingredient Dictionary

BETA-CARYOPHYLLENE

(-)-beta-caryophyllene is a beta-caryophyllene in which the stereocentre adjacent to the exocyclic double bond has S configuration while the remaining stereocentre has R configuration.

How much products actually contain

No product states its amount yet.

Of the products containing it, 14 list it before the 1% line and 96 after it (usually 1% or less).

Products using this ingredient

12 of 110 confirmed · likeliest to carry enough first · See all 110

Definition

(-)-beta-caryophyllene is a beta-caryophyllene in which the stereocentre adjacent to the exocyclic double bond has S configuration while the remaining stereocentre has R configuration. It is the most commonly occurring form of beta-caryophyllene, occurring in many essential oils, particularly oil of cloves. It has a role as an insect attractant, a metabolite, a non-steroidal anti-inflammatory drug and a fragrance. It is an enantiomer of a (+)-beta-caryophyllene.

Source: PubChem

US FDA substance register · UNII BHW853AU9H · registered name CARYOPHYLLENE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Gives the product a scentPERFUMINGKeeps skin in good condition (CosIng catch-all)SKIN CONDITIONINGListed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCE

Safety & regulatory references

European Union

Other : The presence of the substance shall be indicated in the list of ingredients referred to in Article 19(1), point (g), when its concentration exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products.

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 332

Source: EU restricted substances (Annex III)

Restriction III/332

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name β－カリオフィレン: 本品は、次の化学式で表されるセスキテルペン炭化水素である。

Source: JCIA labelling names (Japan)

Names & identifiers

BETA-CARYOPHYLLENEINCI베타-카리오필렌Korean label name (MFDS standard)Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, [1R-(1R*,4E,9S*)]-Synonymβ－カリオフィレンJapanese labelling name

CAS No.chemical registry number: 87-44-5
EC No.EU chemical inventory number: 201-746-1
EC No.EU chemical inventory number: 291-746-1
DTXSIDUS EPA chemical ID: DTXSID8024739
DTXCIDUS EPA compound ID: DTXCID304739

IUPAC: (1R,4E,9S)-4,11,11-Trimethyl-8-methylidenebicyclo[7.2.0]undec-4-ene
Molecular formula: C15H24
Molecular weight: 204.357 g/mol

Measured properties

Appearance: liquid
Melting/freezing point: &amp, lt, -100 ℃
Initial boiling point and range: 253~262 ℃
Flash point: 105.5 ℃
Vapour pressure: 0.06
Water solubility: 0.088 ㎎/ℓ (20 °C, pH:7)
Relative density: 0.901
n-Octanol/water partition coefficient (Kow): 6.23
Auto-ignition temperature: 215 ℃ (1021.1-1022.1hPa)
Molecular weight: 204.3546

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 129 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance120
Flavouring and nutrient3
Softener and conditioner3
Deodorizer2
Dye1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 1 eye studies are on record.

Classed as moderate2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

Low to Moderate Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
SkinIrr2
Skin Irritation · QSAR Predicted
Low to Moderate Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) 1987 according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) 1997 according to