Betulin is a pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.
How much products actually contain
No product states its amount yet.
Of the products containing it, 5 list it before the 1% line and 7 after it (usually 1% or less).
Products using this ingredient
12 of 12 confirmed · likeliest to carry enough first
FeevHyper Hydro Cream
OSEAOSEA Seabiotic® Water Cream
ROUND LABROUND LAB Birch Moisturizing Lip Balm 20g
ROUND LABBirch Moisturizing Sun Spray 100ml
ROUND LABROUND LAB Birch Moisturizing Sun Spray 100ml
SUISKINWhite Birch Sap Ampoule
Biome ActivatePanthenol 7% Ampoule
ROUND LABROUND LAB Birch Moisturizing Double Gel Mask (10 Sheets)
A'demangUltra 4EGF Cream
ROUND LABROUND LAB Birch Moisturizing Sun Serum 50ml
AGE 20'sAGE 20's Sun Essence Pact Mineral Calming
atheSun Essence EX / Mineral Sun Cream 50ml 2 Types
Definition
Betulin is a pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents. It has a role as an antiviral agent, a metabolite, an analgesic, an antineoplastic agent and an anti-inflammatory agent. It is a diol and a pentacyclic triterpenoid. It derives from a hydride of a lupane.
Source: PubChem
US FDA substance register · UNII 6W70HN7X7O · registered name BETULIN · single chemical substance
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ベツリン: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 473-98-3
- EC No.EU chemical inventory number
- 207-475-5
- DTXSIDUS EPA chemical ID
- DTXSID101019934
- DTXCIDUS EPA compound ID
- DTXCID801477793
- IUPAC
- Lup-20(29)-ene-3beta,28-diol
- Molecular formula
- C30H50O2
- Molecular weight
- 442.728 g/mol
Measured properties
- Appearance
- Solid
- Boiling point
- 284.00 to 288.00 °C. @ 743.00 mm Hg
- Melting point
- 251 - 252 °C
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- An overview of betulin: botanical source, derivatives and biological potential: Mini Review · 2025
- Evaluation of betulin for hair growth promoting activity in rats · 2024
- Effect of Betulin Colloidal Particles on Proliferation and Cytokine Secretion of Human Skin Fibroblasts · 2023
- BETULIN INTEGRATION METHOD INTO SOLUTIONS FOR NEEDLELESS ELECTROSPINNING · 2022
- Enhancement of the Antioxidant and Skin Permeation Properties of Betulin and Its Derivatives · 2021
Linked databases 17
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese