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Ingredient Dictionary

BHT

2,6-di-tert-butyl-4-methylphenol is a member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.

Molecular structure

How much products actually contain

No product states its amount yet.

Of the products containing it, 241 list it before the 1% line and 607 after it (usually 1% or less).

Products using this ingredient

12 of 844 confirmed · likeliest to carry enough first · See all 844

Definition

US FDA substance register · UNII 1P9D0Z171K · registered name Butylated hydroxytoluene · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

2,6-di-tert-butyl-4-methylphenol is a member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6. It has a role as a ferroptosis inhibitor, a geroprotector, an antioxidant and a food additive. It is functionally related to a phenol.

Source: PubChem

BHT is a substituted toluene that conforms to the formula:

Cosmetic roles

Listed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCESlows spoilage by oxygenANTIOXIDANT

Safety & regulatory references

Restricted
ASEAN · European Union · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

유럽

  • Product Type, body parts : (a) Mouthwash (b) Toothpaste (c) Other leave-on and rinse-off products
  • Maximum concentration in ready for use preparation : (a) 0,001 % (b) 0,1 % (c) 0,8 %

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 325 · maximum concentration a) 0,001 % b) 0,1 % c) 0,8 % · applies to a) Mouthwash b) Toothpaste c) Other leave-on and rinse-off products

Source: EU restricted substances (Annex III)

Restriction III / 325

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of BHT (Butylated Hydroxytoluene)

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: BHT - Butylated Hydroxytoluene

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ＢＨＴ: 本品は、次の化学式で表されるトルエン誘導体である。

Source: JCIA labelling names (Japan)

Names & identifiers

BHTINCI비에이치티Korean label name (MFDS standard)Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-Synonym
CAS No.chemical registry number
128-37-0
EC No.EU chemical inventory number
204-881-4
DTXSIDUS EPA chemical ID
DTXSID2020216
DTXCIDUS EPA compound ID
DTXCID20216
IUPAC
2,6-Di-tert-butyl-4-methylphenol
Molecular formula
C15H24O
Molecular weight
220.356 g/mol

Measured properties

Appearance
Butylated hydroxytoluene is a white crystalline solid. (NTP, 1992) · Other Solid, Dry Powder, CBI, Large Crystals, Liquid
Odour
Very faint, musty, occasional cresylic-type odor · odourless
Boiling point
509 °F at 760 mmHg (NTP, 1992) · 265 °C
Melting point
156 to 160 °F (NTP, 1992) · 70 °C
Solubility
less than 1 mg/mL at 68 °F (NTP, 1992) · Insoluble in water and propane- 1,2-diol, Freely soluble in ethanol
Density
1.048 at 68 °F (NTP, 1992) - Denser than water, will sink · 1.048 at 20 °C/4 °C
Colour
colourless
Melting/freezing point
70 ℃
Initial boiling point and range
265 ℃
Flash point
127 ℃(c.c.)
Vapour pressure
1.3 ㎜Hg(20℃)
Water solubility
0 g/100㎖(25℃)
Vapour density
7.6
Relative density
1.048
n-Octanol/water partition coefficient (Kow)
5.1
Viscosity
3.47 cP(0℃, centistokes)
Molecular weight
220.3536

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 625 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Fragrance222
  • Antioxidant195
  • Preservative90
  • Processing aids not otherwise specified43
  • Stabilizing agent36
  • Defoamer8
  • Lubricating agent5
  • UV stabilizer5
11 other uses
  • Degradant/impurity (EPA)4
  • Flavouring and nutrient3
  • Reducing agent2
  • Deodorizer2
  • Film former2
  • Dispersing agent2
  • Fuel2
  • Pharmaceutical (EPA)1
  • Emulsifier1
  • Elasticizer1
  • Solvent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 2 eye studies are on record.

Classed as low3

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies
  • Not likely to be sensitizing
    skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Magnusson and Kligman (1969)
  • Category 6.5B (Category 1)
    Skin Sensitization · Read Across
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
  • Not classified
    Skin Irritation · Screening
  • Classification not possible
    Skin Sensitization · Screening
  • SkinIrr2
    Skin Irritation · QSAR Predicted
  • Category 2B
    Eye Irritation · Screening
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to

Source: US EPA CompTox dashboard

Related literature

Linked databases 29

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