Bilirubin IXalpha is a member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type.
Definition
Bilirubin IXalpha is a member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin. It has a role as an antioxidant, a mouse metabolite and a human metabolite. It is a dicarboxylic acid and a member of biladienes. It contains a 24G7 epitope. It is a conjugate acid of a bilirubin(2-).
Source: PubChem
US FDA substance register · UNII RFM9X3LJ49 · registered name BILIRUBIN · single chemical substance
Bilirubin is a red-orange colored metabolite formed during the breakdown of hemoglobin in vertebrates that conforms to the formula
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ビリルビン: 本品は、次の化学式で表される脊椎動物のヘモグロビンの分解中に形成される赤橙色の代謝物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 635-65-4
- EC No.EU chemical inventory number
- 211-239-7
- DTXSIDUS EPA chemical ID
- DTXSID8060905
- DTXCIDUS EPA compound ID
- DTXCID40162318
- IUPAC
- 3-{2-({3-(2-Carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)meth yl]-4-methyl-1H-pyrrol-3-yl}propanoic acid
- Molecular formula
- C33H36N4O6
- Molecular weight
- 584.673 g/mol
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Correlation of Neonatal Hyperbilirubinemia by Clinical Assessment, Total Serum Bilirubin and Transcutaneous Bilirubin among Healthy Neonates · 2018
- Is there any Relation of Urine Bilirubin with Dimple on Chin? · 2019
- Skin residual bilirubin volume: a physiologically informed framework for transcutaneous bilirubin interpretation in neonates · 2026
- Serum Unbound Bilirubin Versus Transcutaneous Bilirubin in Jaundiced Term Neonates · 2020
- A Comparison between Transcutaneous Bilirubin (TcB) and Total Serum Bilirubin (TSB) Measurements in Term Neonates · 2019
Linked databases 16
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese