Ingredient Dictionary

BIOTIN

Biotin is an organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring.

How much products actually contain

71 products state the amountmedian 0.00001%

under 0.01% 69
0.01–0.1% 2
0.1–1% 0
1% or more 0

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

Of the products containing it, 205 list it before the 1% line and 537 after it (usually 1% or less).

Products using this ingredient

12 of 734 confirmed · likeliest to carry enough first · See all 734

Definition

Biotin is an organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins. It has a role as a coenzyme, a cofactor, a prosthetic group, a nutraceutical, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and a fundamental metabolite. It is a vitamin B7 and a member of biotins. It is a conjugate acid of a biotinate.

Source: PubChem

US FDA substance register · UNII 6SO6U10H04 · registered name BIOTIN · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Biotin is the organic compound that conforms to the formula

Cosmetic roles

Softens hairHAIR CONDITIONINGSkin conditioning not covered aboveSKIN CONDITIONING - MISCELLANEOUS

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: Final Report on the Safety Assessment of Biotin

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Biotin

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ビオチン: 本品は、次の化学式で表される複素環式化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

BIOTININCI바이오틴Korean label name (MFDS standard)1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS,4S,6aR)-SynonymビオチンJapanese labelling name

CAS No.chemical registry number: 58-85-5
EC No.EU chemical inventory number: 200-399-3
DTXSIDUS EPA chemical ID: DTXSID7022679
DTXCIDUS EPA compound ID: DTXCID201527506

IUPAC: 5-[(3aR,4S,6aS)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid
Molecular formula: C10H16N2O3S
Molecular weight: 244.31 g/mol

Measured properties

Appearance: Solid, [Merck Index] White powder, [Sigma-Aldrich MSDS] · Solid
Melting point: 232 dec °C · 232 °C (decomposes)
Solubility: 220 mg/L (at 25 °C) · SOL IN ACETONE, DISSOLVES ABOUT 1 PART/100 IN METHANOL, SOL IN METHYL ETHYL KETONE, BENZENE, CYCLOHEXENE, INSOL IN SATURATED & PARAFFIN HYDROCARBONS /METHYL ESTER/
Stability: PURE CMPD IS STABLE TO AIR & TEMP, MODERATELY ACID & NEUTRAL SOLN ARE STABLE SEVERAL MO, ALKALINE REASONABLY STABLE TO PH 9 · STABILITY IN DRY PRODUCTS IS EXCELLENT, PHARMACEUTICAL LIQ PRODUCTS INDICATE LOSSES OF 0-8% @ PH 5-8 AFTER 1 YR @ ROOM TEMP
Colour: white
pH: 4.5
Melting/freezing point: 232 ℃
Flash point: &amp, gt, 93.3 ℃
Vapour pressure: 0.0000000107 ㎜Hg (at 25 ℃)
Water solubility: 220 ppm (at 25 ℃)
n-Octanol/water partition coefficient (Kow): 0.390
Molecular weight: 244.31

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 36 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner23
Pharmaceutical (EPA)11
Flavouring and nutrient1
Chelating agent1

Source: US EPA CompTox dashboard