Ingredient Dictionary

BIS-HYDROXYETHYL TROMETHAMINE

Bis-tris is a buffer substance useful for calibration of glass electrodes and for the preparation of the biochemical and biological buffer solutions; pKa = 6.46 at 25 C.

Definition

Bis-tris is a buffer substance useful for calibration of glass electrodes and for the preparation of the biochemical and biological buffer solutions; pKa = 6.46 at 25 C. It has a role as a buffer. It is functionally related to a member of tris.

Source: PubChem

US FDA substance register · UNII Q1XC3631CP · registered name BISTRIS · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps pH steadyBUFFERING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ビスヒドロキシエチルトロメタミン: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

BIS-HYDROXYETHYL TROMETHAMINEINCI비스-하이드록시에틸트로메타민Korean label name (MFDS standard)1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-SynonymビスヒドロキシエチルトロメタミンJapanese labelling name

CAS No.chemical registry number: 6976-37-0
EC No.EU chemical inventory number: 230-237-7
DTXSIDUS EPA chemical ID: DTXSID6064537
DTXCIDUS EPA compound ID: DTXCID0046563

IUPAC: 2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
Molecular formula: C8H19NO5
Molecular weight: 209.242 g/mol

Measured properties

Appearance: solid
Colour: white
pH: 5.5-8.0
Melting/freezing point: 102~103 ℃
n-Octanol/water partition coefficient (Kow): -2.48
Molecular weight: 209.24

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

pH regulating agent1
Intermediate1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 0 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 1 studies

SkinIrr2
Skin Irritation · QSAR Predicted