What is this ingredient?

미국 FDA 물질 등록 · UNII JOV61FMS35 · 등록명 BIS-TRIMETHYLBENZOYL PHENYLPHOSPHINE OXIDE · 단일 화학물질

All ingredients

Ingredient Dictionary

BIS-TRIMETHYLBENZOYL PHENYLPHOSPHINE OXIDE

Bis-Trimethylbenzoyl Phenylphosphine Oxide is the organic compound.

How much products actually contain

No product states its amount yet.

Of the products containing it, 7 list it before the 1% line and 0 after it (usually 1% or less).

Products using this ingredient

7 of 7 confirmed · likeliest to carry enough first

Definition

US FDA substance register · UNII JOV61FMS35 · registered name BIS-TRIMETHYLBENZOYL PHENYLPHOSPHINE OXIDE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Bis-Trimethylbenzoyl Phenylphosphine Oxide is the organic compound.

Cosmetic roles

Protects colour and scent from lightLIGHT STABILIZER

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

CIR reviewed this ingredient and flagged its status as: Insufficient Data Announcement: Safety Assessment of Bis Trimethylbenzoyl PhenylphosphineOxide, Ethyl Trimethylbenzoyl Phenylphosphinate, andTrimethylbenzoyl Diphenylphosphine Oxide (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ビストリメチルベンゾイルフェニルホスフィンオキシド: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

BIS-TRIMETHYLBENZOYL PHENYLPHOSPHINE OXIDEINCI비스-트라이메틸벤조일페닐포스핀옥사이드Korean label name (MFDS standard)Methanone, 1,1′-(phenylphosphinylidene)bis[1-(2,4,6-trimethylphenyl)-SynonymビストリメチルベンゾイルフェニルホスフィンオキシドJapanese labelling name

CAS No.chemical registry number: 162881-26-7
DTXSIDUS EPA chemical ID: DTXSID8044597
DTXCIDUS EPA compound ID: DTXCID6024597

IUPAC: Phenylbis(2,4,6-trimethylbenzoyl)-lambda~5~-phosphanone
Molecular formula: C26H27O3P
Molecular weight: 418.473 g/mol

What products actually use it for

What the 13 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Photosensitizers6
Processing aids not otherwise specified3
Photosensitive agent2
Catalyst1
Stabilizing agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

15 skin studies and 5 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 20 studies

Skin Sens. 1
Skin Sensitization · Authoritative
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: 92/69/EEC (maximisation), B.6
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: 92/69/EEC (maximisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) (92/69/EEC) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: 92/69/EEC, B.4 according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: 92/69/EEC according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) (Directive 92/69/EEC) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to EU Method B.6 (Skin Sensitisation)
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: 92/69/EEC (Maximisation)
Ambiguous
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: 92/69/EEC
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) (1992)
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to EU Method B.6 (Skin Sensitisation) (Directive 92/69/EEC)
Ambiguous
skin sensitisation · Screening · according to other guideline: 92/69/EEC (Maximisation)
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: 92/69/EEC according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) (92/69/EEC) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) (Directive 92/69/EEC) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: 92/69/EEC, B.5 according to