Borneol is a bornane monoterpenoid that is 1,7,7-trimethylbicyclo[2.2.1]heptane substituted by a hydroxy group at position 2.
Definition
Borneol is a bornane monoterpenoid that is 1,7,7-trimethylbicyclo[2.2.1]heptane substituted by a hydroxy group at position 2. It has a role as a metabolite and a volatile oil component.
Source: PubChem
US FDA substance register · UNII M89NIB437X · registered name BORNEOL · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ボルネオール: 本品は、次の化学式で表されるテルペンアルコールである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 507-70-0
- EC No.EU chemical inventory number
- 208-080-0
- DTXSIDUS EPA chemical ID
- DTXSID3052143
- DTXCIDUS EPA compound ID
- DTXCID3032387
- IUPAC
- (1R,2S,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol
- Molecular formula
- C10H18O
- Molecular weight
- 154.253 g/mol
Measured properties
- Appearance
- Borneol appears as a white colored lump-solid with a sharp camphor-like odor. Burns readily. Slightly denser than water and insoluble in water. Used to make perfumes. · Liquid
- Odour
- Piney, camphor-like odor
- Boiling point
- 212 °C
- Melting point
- 202 °C · Hexanogal plates from petroleum ether, melting point: 204 °C, boiling point: 210 °C at 779 mm Hg /L-Borneol/
- Solubility
- In water, 738 mg/L at 25 °C · Slightly soluble in propylene glycol
- Density
- Leaves from ligroin, MP 206 °C, BP 213 °C, density: 1.011 g/cu cm at 20 °C. Insoluble in water, very soluble in ethanol, ether, benzene /Borneol, (+/-)-/
- Colour
- colourless
- Melting/freezing point
- 210.5 ℃
- Initial boiling point and range
- 212 ℃
- Flash point
- 66 ℃
- Upper/lower flammability or explosive limits
- 3.5 / 0.6 %
- Vapour pressure
- 0.0353 ㎜Hg (25℃)
- Water solubility
- 738 ㎎/ℓ (25℃)
- Vapour density
- 5.31
- Relative density
- 1.011 (20℃/4℃)
- n-Octanol/water partition coefficient (Kow)
- 2.69
- Auto-ignition temperature
- 871 ℉
- Molecular weight
- 154.24
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 33 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Fragrance29
- Flavouring and nutrient3
- Deodorizer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 6 studies
- Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 6.3B (Category 3)
Skin Irritation · Read Across - Classification not possible
Skin Sensitization · Screening - Classification not possible
Skin Irritation · Screening - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Classification not possible
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Borneol exerts its antipruritic effects by inhibiting TRPA1 and activating TRPM8. · 2023
- Design, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome · 2019
- A clinical and mechanistic study of topical borneol‐induced analgesia · 2017
- Research progress on the pharmacokinetic profile of borneol · 2015
- External Application of Borneol to Inhibit Acute Pain after Injury in Rats · 2010
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese