Bromophenol blue is 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3,5-dibromo-4-hydroxyphenyl groups.
Definition
Bromophenol blue is 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3,5-dibromo-4-hydroxyphenyl groups. It is used as a laboratory indicator, changing from yellow below pH 3 to purple at pH 4.6, and as a size marker for monitoring the progress of agarose gel and polyacrylamide gel electrophoresis. It has also been used as an industrial dye. It has a role as a dye, an acid-base indicator and a two-colour indicator. It is a member of phenols, an organobromine compound, a 2,1-benzoxathiole, a sultone and an arenesulfonate ester.
Source: PubChem
US FDA substance register · UNII 0R2969YC90 · registered name BROMOPHENOL BLUE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 115-39-9
- EC No.EU chemical inventory number
- 204-086-2
- DTXSIDUS EPA chemical ID
- DTXSID6041682
- DTXCIDUS EPA compound ID
- DTXCID4021682
- IUPAC
- 3,3-Bis(3,5-dibromo-4-hydroxyphenyl)-2,1lambda~6~-benzoxathiole-1,1(3H)-dione
- Molecular formula
- C19H10Br4O5S
- Molecular weight
- 669.96 g/mol
Measured properties
- Appearance
- Odorless solid, Color varies (tan, orange, light pink, purple, or red) [CHEMINFO] Slightly soluble in water, [MSDSonline] · Hexagonal prisms from acetic acid and acetone
- Melting point
- Decomposes at 279 °C (An orange discoloration with formation of a green sublimate sets in at 210 °C)
- Solubility
- Soluble in acetic acid · Soluble in water (about 0.4 g/100 mL), more soluble in methyl and ethyl alcohol, and in benzene. Freely soluble in NaOH solutions with the formation of a water-soluble sodium salt.
- Dissociation constant
- pKa = 4.0
- Odour
- odourless
- Melting/freezing point
- 273 ℃
- Upper/lower flammability or explosive limits
- - / - %
- Water solubility
- 0.04061 ㎎/ℓ
- Molecular weight
- 669.96
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Biocide1
- Antioxidant1
Source: US EPA CompTox dashboard
Related literature
- ELECTROPHORESIS OF SOLUBLE PROTEINS EXTRACTED FROM CELL SUSPENSIONS OF NEO t ATAL RAT EPlDERMl * · 2010
- Analysis of haemolymph proteins in the Brugia malayi-susceptible mosquito, Aedes togoi, using SDS-PAGE and two-dimensional gel electrophoresis. · 2011
- Analysis of collagen type III by uninterrupted sodium dodecyl sulfate‐polyacrylamide gel electrophoresis and immunoblotting: Changes in collagen type III polymorphism in aging rats · 1992
- Use of Bromphenol Blue Printing Method for Detecting Sweat on the Palm · 1986
- Surface secretions of the skin of Blennius (Lipophrys) pholis L. · 1984
Linked databases 17
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese