Definition
US FDA substance register · UNII 7ZF18Q354W · registered name BUMETRIZOLE · single chemical substance
Bumetrizole is the organic compound that conforms to the formula
Cosmetic roles
Protects colour and scent from lightLIGHT STABILIZER
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ブメトリゾール: 本品は、次の化学式で表される複素環式化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
BUMETRIZOLEINCI부메트라이졸Korean label name (MFDS standard)Phenol, 2-(5-chloro-2H-benzotriazol-2-yl)-6-(1,1-dimethylethyl)-4-methyl-SynonymブメトリゾールJapanese labelling name
- CAS No.chemical registry number
- 3896-11-5
- EC No.EU chemical inventory number
- 223-445-4
- DTXSIDUS EPA chemical ID
- DTXSID9036438
- DTXCIDUS EPA compound ID
- DTXCID7016438
- IUPAC
- 2-tert-Butyl-6-(5-chloro-2H-1,2,3-benzotriazol-2-yl)-4-methylphenol
- Molecular formula
- C17H18ClN3O
- Molecular weight
- 315.8 g/mol
Measured properties
- Appearance
- solid
- Flammability (solid, gas)
- combustible
- Vapour pressure
- (at 20 C)
- Water solubility
- (4 μg/L @ 20 ℃)
- Vapour density
- 10.9
- Relative density
- 1.32 (20 ℃)
- n-Octanol/water partition coefficient (Kow)
- (&, gt, 6.5 @ 23 ℃)
- Auto-ignition temperature
- 420 ℃
- Decomposition temperature
- (&, gt, 225 ℃)
- Molecular weight
- 315.802
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 55 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- UV stabilizer45
- Antioxidant3
- Fragrance2
- Processing aids not otherwise specified2
- Surface modifier2
- Photosensitive agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
9 skin studies and 3 eye studies are on record.
Classed as low7
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 12 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Proposed Guidelines of the US EPA s 163.81-5 'Primary dermal irritation study' (1978-08-22) according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Proposed Guidelines of the US EPA 40CFR 163.81-5 'Primary dermal irritation study' according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Ambiguous
skin sensitisation · Screening · according to other guideline: OECD Draft Guideline: Acute Dermal Photoirritation Dose-Response Test, February 1995 according to other guideline: CTFA Safety Testing Guidelines: The Cosmetic, Toiletry and Fragrance Association, Inc. Washington, DC 20036; Guidelines for Evaluating Photodermatitis, 1991 - Category 6.5B (Category 1)
Skin Sensitization · Read Across - SkinIrr2
Skin Irritation · QSAR Predicted - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Not likely to be sensitizing
skin sensitisation · Screening · according to other guideline: OECD Draft Guideline: Acute Dermal Photoirritation Dose-Response Test, February 1995 according to other guideline: CTFA Safety Testing Guidelines: The Cosmetic, Toiletry and Fragrance Association, Inc. Washington, DC 20036; Guidelines for Evaluating Photodermatitis, 1991 - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: US FDA, Federal Register 191.12, 17 September 1964 according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Source: US EPA CompTox dashboard
Related literature
- Antimicrobial Activity, Antioxidant Potential, Cytotoxicity and Phytochemical Profiling of Four Plants Locally Used against Skin Diseases · 2019
- Evaluation of Spirulina spp. Crude Extract Revealed Antimicrobial, Antioxidant and UV Photoprotective Properties · 2024
- Environmental occurrence and distribution of organic UV stabilizers and UV filters in the sediment of Chinese Bohai and Yellow Seas. · 2018
- Influence of the Photostabilizer in the Photoprotective Effects of a Formulation Containing UV‐Filters and Vitamin A · 2010
Linked databases 16
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- Tlooto literature search 2 3 4
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata