定义
美国FDA 物质登记 · UNII 7ZF18Q354W · 登记名称 BUMETRIZOLE · 单一化学物质
Bumetrizole is the organic compound that conforms to the formula
化妆品中的作用
防止光照导致颜色和香味变化LIGHT STABILIZER
安全与法规参考
未列入韩国有毒物质 GHS 分类 · 现有化学物质
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 ブメトリゾール: 本品は、次の化学式で表される複素環式化合物である。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
BUMETRIZOLEINCI부메트라이졸韩国标示名称（食药处标准名）Phenol, 2-(5-chloro-2H-benzotriazol-2-yl)-6-(1,1-dimethylethyl)-4-methyl-同义名ブメトリゾール日本标示名称
- CAS No.化学物质登记号
- 3896-11-5
- EC No.欧盟化学品目录编号
- 223-445-4
- DTXSID美国EPA化学品编号
- DTXSID9036438
- DTXCID美国EPA化合物编号
- DTXCID7016438
- IUPAC
- 2-tert-Butyl-6-(5-chloro-2H-1,2,3-benzotriazol-2-yl)-4-methylphenol
- 分子式
- C17H18ClN3O
- 分子量
- 315.8 g/mol
实测物性
- 性状
- 固体
- 易燃性（固体、气体）
- 可燃
- 蒸气压
- (at 20 C)
- 溶解度
- (4 μg/L @ 20 ℃)
- 蒸气密度
- 10.9
- 比重
- 1.32 (20 ℃)
- 正辛醇/水分配系数（Kow）
- (&, gt, 6.5 @ 23 ℃)
- 自燃温度
- 420 ℃
- 分解温度
- (&, gt, 225 ℃)
- 分子量
- 315.802
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 55 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- UV stabilizer45
- Antioxidant3
- Fragrance2
- Processing aids not otherwise specified2
- Surface modifier2
- Photosensitive agent1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 9 项、眼部试验 3 项。
归类为低7 项
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 12 项试验
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Proposed Guidelines of the US EPA s 163.81-5 'Primary dermal irritation study' (1978-08-22) according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Proposed Guidelines of the US EPA 40CFR 163.81-5 'Primary dermal irritation study' according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · equivalent or similar to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Ambiguous
skin sensitisation · Screening · according to other guideline: OECD Draft Guideline: Acute Dermal Photoirritation Dose-Response Test, February 1995 according to other guideline: CTFA Safety Testing Guidelines: The Cosmetic, Toiletry and Fragrance Association, Inc. Washington, DC 20036; Guidelines for Evaluating Photodermatitis, 1991 - Category 6.5B (Category 1)
Skin Sensitization · Read Across - SkinIrr2
Skin Irritation · QSAR Predicted - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Not likely to be sensitizing
skin sensitisation · Screening · according to other guideline: OECD Draft Guideline: Acute Dermal Photoirritation Dose-Response Test, February 1995 according to other guideline: CTFA Safety Testing Guidelines: The Cosmetic, Toiletry and Fragrance Association, Inc. Washington, DC 20036; Guidelines for Evaluating Photodermatitis, 1991 - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: US FDA, Federal Register 191.12, 17 September 1964 according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
来源: 美国EPA CompTox
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