Butyl Glycolate is the ester of butyl alcohol and glycolic acid.
Definition
US FDA substance register · UNII 3H5QAS0HZX · registered name BUTYL GLYCOLATE · single chemical substance
Butyl Glycolate is the ester of butyl alcohol and glycolic acid.
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015
Reviewed by CIR: Final Report on the Safety Assessment of Glycolic Acid, Ammonium, Calcium, Potassium, and Sodium Glycolates, Methyl, Ethyl, Propyl, and Butyl Glycolates, and Lactic Acid, Ammonium, Calcium, Potassium, Sodium, and TEA-Lactates, Methyl, Ethyl, Isopropyl, and Butyl Lactates, and Lauryl, Myristyl, and Cetyl Lactates
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 7397-62-8
- EC No.EU chemical inventory number
- 230-991-7
- DTXSIDUS EPA chemical ID
- DTXSID6044725
- DTXCIDUS EPA compound ID
- DTXCID4024725
- IUPAC
- Butyl hydroxyacetate
- Molecular formula
- C6H12O3
- Molecular weight
- 132.159 g/mol
Measured properties
- Appearance
- liquid
- Colour
- colourless
- pH
- 7
- Melting/freezing point
- -26 ℃
- Initial boiling point and range
- 180 ℃
- Flash point
- 68 ℃(c.c.)
- Vapour pressure
- (1.33 hPa at 20℃)
- Water solubility
- 20000 ㎎/ℓ(at 20℃)
- Vapour density
- 4.45
- Relative density
- 1.015 (1.015-1.023 at 20℃)
- n-Octanol/water partition coefficient (Kow)
- 1.057
- Auto-ignition temperature
- 405 ℃
- Molecular weight
- 132.16
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Processing aids not otherwise specified3
- Solvent2
- Softener and conditioner1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 7 studies
- Not classified
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: MAFF Japan Testing Guidelines Dermal Sensitization according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) according to EPA OPPTS 870.2600 (Skin Sensitisation) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to - Category 2
Eye Irritation · Screening - Severe Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) equivalent or similar to OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Source: US EPA CompTox dashboard
Related literature
Linked databases 14
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- Tlooto literature search
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata