What is this ingredient?

미국 FDA 물질 등록 · UNII OL659KIY4X · 등록명 Butyrolactone · 단일 화학물질

All ingredients

Ingredient Dictionary

BUTYROLACTONE

Gamma-butyrolactone is a butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.

Definition

US FDA substance register · UNII OL659KIY4X · registered name Butyrolactone · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Gamma-butyrolactone is a butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2. It has a role as a metabolite and a neurotoxin.

Source: PubChem

Butyrolactone is the lactone that conforms to the formula

Cosmetic roles

Base that dissolves other ingredientsSOLVENTListed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCEGives the product a scentPERFUMING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ブチロラクトン: 本品は、次の化学式で表されるラクトンである。

Source: JCIA labelling names (Japan)

Names & identifiers

BUTYROLACTONEINCI부티로락톤Korean label name (MFDS standard)2(3H)-Furanone, dihydro-SynonymブチロラクトンJapanese labelling name

CAS No.chemical registry number: 96-48-0
EC No.EU chemical inventory number: 202-509-5
DTXSIDUS EPA chemical ID: DTXSID6020224
DTXCIDUS EPA compound ID: DTXCID80224

IUPAC: Oxolan-2-one
Molecular formula: C4H6O2
Molecular weight: 86.09 g/mol

Measured properties

Appearance: 4-butyrolactone is a clear colorless oily liquid with a pleasant odor. (NTP, 1992) · Liquid
Odour: Pleasant odor · Faint odor
Boiling point: 399 to 401 °F at 760 mmHg (NTP, 1992) · 204 °C at 760 mm Hg
Melting point: -49 °F (NTP, 1992) · -43.53 °C
Solubility: greater than or equal to 100 mg/mL at 55 °F (NTP, 1992) · Miscible with alcohol and ether.
Density: 1.1286 at 59 °F (NTP, 1992) - Denser than water, will sink · 1.1296 g/cu cm at 20 °C
Stability: Stable at pH 7, rapidly hydrolyzed by bases, slowly hydrolyzed by acids.
Viscosity: 1.75 centipoise at 25 °C · 1.75 cP (@ 25 ℃)
Colour: colourless
Odour threshold: (20-50 ppm)
Melting/freezing point: -44 ℃
Initial boiling point and range: 204 ℃
Flash point: 98 ℃(c.c.)
Flammability (solid, gas): combustible
Upper/lower flammability or explosive limits: 16 / 0.3 %
Vapour pressure: 0.45 ㎜Hg (0.45 mmHg at 25C)
Water solubility: 1000000 ㎎/ℓ (@ 0 ℃)
Vapour density: 2.97
Relative density: 1.1
n-Octanol/water partition coefficient (Kow): -0.57
Auto-ignition temperature: 455 ℃
Molecular weight: 86.09

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 17 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent8
Fragrance3
Flavouring and nutrient2
Deodorizer1
Intermediate1
Chemical reaction regulator1
Processing aids not otherwise specified1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 3 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies

Classification not possible
Skin Sensitization · Screening
Not classified
Skin Irritation · Screening
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
SkinIrr2
Skin Irritation · QSAR Predicted
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) Eyes were rinsed after treatment according to
Category 2A
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across