Caffeic Acid can cause cancer according to The World Health Organization's International Agency for Research on Cancer (IARC).
How much products actually contain
No product states its amount yet.
Of the products containing it, 3 list it before the 1% line and 0 after it (usually 1% or less).
Products using this ingredient
3 of 3 confirmed · likeliest to carry enough first
Definition
Caffeic Acid can cause cancer according to The World Health Organization's International Agency for Research on Cancer (IARC).
Source: PubChem
US FDA substance register · UNII U2S3A33KVM · registered name CAFFEIC ACID · single chemical substance
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name カフェー酸: 本品は、次の化学式で表される芳香族化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 331-39-5
- EC No.EU chemical inventory number
- 206-361-2
- DTXSIDUS EPA chemical ID
- DTXSID5020231
- DTXCIDUS EPA compound ID
- DTXCID10231
- IUPAC
- 3-(3,4-Dihydroxyphenyl)prop-2-enoic acid
- Molecular formula
- C9H8O4
- Molecular weight
- 180.159 g/mol
Measured properties
- Appearance
- 3,4-dihydroxycinnamic acid appears as yellow prisms or plates (from chloroform or ligroin) or pale yellow granules. Alkaline solutions turn from yellow to orange. (NTP, 1992) · Yellow solid, Slightly soluble in cold water, soluble in hot water, [Merck Index] Light yellow powder, [MSDSonline]
- Melting point
- 433 to 437 °F (decomposes) (NTP, 1992) · 225 dec °C
- Solubility
- less than 1 mg/mL at 72 °F (NTP, 1992) · Sparingly soluble in cold water. Freely soluble in hot water, cold alcohol.
- Dissociation constant
- 4.62 (at 25 °C) · pKa = 4.62 at 25 °C
- Melting/freezing point
- 223~225 ℃
- Initial boiling point and range
- 366 ℃
- n-Octanol/water partition coefficient (Kow)
- 1.15
- Decomposition temperature
- 194-225 ℃
- Molecular weight
- 180.16
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Antioxidant1
- Deodorizer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- SkinIrr2
Skin Irritation · QSAR Predicted - SkinSens1
Skin Sensitization · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- Potential Unlocking of Biological Activity of Caffeic Acid by Incorporation into Hydrophilic Gels · 2024
- Effects of caffeic acid on oxidative balance and cancer · 2021
- Antioxidant and antiaging activity of rutin and caffeic acid · 2020
- Nanoparticulate Gels for Cutaneous Administration of Caffeic Acid · 2020
- Design and Characterization of Ethosomes for Transdermal Delivery of Caffeic Acid · 2020
Linked databases 17
- ChEBI 2
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- IARC carcinogen classification
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata 2