Ingredient Dictionary

CALCIUM DIHYDROGEN PHOSPHATE

Calcium bis(dihydrogenphosphate) is a calcium phosphate.

Definition

Calcium bis(dihydrogenphosphate) is a calcium phosphate. It has a role as a fertilizer.

US FDA substance register · UNII 701EKV9RMN · registered name CALCIUM PHOSPHATE, MONOBASIC, ANHYDROUS · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps pH steadyBUFFERING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Safety Assessment of Phosphoric Acid and Its Salts as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

CALCIUM DIHYDROGEN PHOSPHATEINCI칼슘다이하이드로젠포스페이트Korean label name (MFDS standard)Phosphoric acid, calcium salt (2:1)Synonym

CAS No.chemical registry number: 7758-23-8
EC No.EU chemical inventory number: 231-837-1
DTXSIDUS EPA chemical ID: DTXSID2044262
DTXCIDUS EPA compound ID: DTXCID0024262

IUPAC: Calcium bis(dihydrogen phosphate)
Molecular formula: CaH4O8P2
Molecular weight: 234.05 g/mol

Measured properties

Appearance: Large Crystals, Dry Powder · Granular powder or white, deliquescent crystals or granules
Solubility: Solubility: Cold water 1.8 g/100 cc @ 30 °C, decomposes in hot water. /Calcium phosphate monobasic monohydrate/ · SOL IN DIL HYDROCHLORIC ACID, MODERATELY SOL IN WATER, SOL IN NITRIC ACID OR ACETIC ACID
Density: 2.220 @ 18 °C/4 °C
Colour: white
Odour: odourless
Melting/freezing point: 100 ℃
Vapour pressure: 0 ㎩(at 20 ℃)
Water solubility: 18000 ㎎/ℓ(at 20 ℃, in water)
Vapour density: 8.1
Relative density: 2.22
Decomposition temperature: 200 ℃
Molecular weight: 234.06

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 19 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Flavouring and nutrient4
Soil amendments4
Leavening agent (EPA)3
pH regulating agent2
Food preservative (EPA)1
Filler1
Stabilizing agent1
Thickening agent1

2 other uses

Chelating agent1
Pigment1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 3 eye studies are on record.

Classed as low3

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) 1992
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EPA OPPTS 870.2500 (Acute Dermal Irritation) equivalent or similar to OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · EPA OPPTS 870.2400 (Acute Eye Irritation) equivalent or similar to OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to