Ingredient Dictionary

CALCIUM DISODIUM EDTA

EDTA monocalcium diisodium salt is an organic calcium salt of EDTA diisodium.

Definition

EDTA monocalcium diisodium salt is an organic calcium salt of EDTA diisodium. It is a chelating agent that is used for the treatment of lead poisoning. It has a role as a geroprotector, a chelator and an antidote. It contains an EDTA disodium salt (anhydrous).

Source: PubChem

US FDA substance register · UNII 8U5D034955 · registered name Edetate calcium disodium anhydrous · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Binds metal ions to prevent spoilageCHELATING

Safety & regulatory references

Allowed colourant: United States

Source: US FDA prohibited and restricted ingredients

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: EDTA and Salts

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, HEDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, and Trisodium HEDTA

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name ＥＤＴＡ（Ｃａ／２Ｎａ）: 本品は、エチレンジアミン四酢酸（ＥＤＴＡ（＊））のカルシウム二ナトリウム塩であり、次の化学式で表されるジアミン誘導体である。

Source: JCIA labelling names (Japan)

Names & identifiers

CALCIUM DISODIUM EDTAINCI칼슘다이소듐이디티에이Korean label name (MFDS standard)Calciate(2-), [[N,N′-1,2-ethanediylbis[N-[(carboxy-.kappa.O)methyl]glycinato-.kappa.N,.kappa.O]](4-)]-, sodium (1:2), (OC-6-21)-SynonymＥＤＴＡ（Ｃａ／２Ｎａ）Japanese labelling name

CAS No.chemical registry number: 62-33-9
EC No.EU chemical inventory number: 200-529-9
DTXSIDUS EPA chemical ID: DTXSID2036409
DTXCIDUS EPA compound ID: DTXCID0016409

IUPAC: Calcium sodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate (1/2/1)
Molecular formula: C10H12CaN2Na2O8
Molecular weight: 374.27 g/mol

Measured properties

Appearance: CBI, Other Solid, Dry Powder, Liquid · White, odourless crystalline granules or white to nearly white powder, slightly hygroscopic
Odour: Odorless · odourless
Melting point: >300
Solubility: Powder. Solubility in water: at 20 °C a 0.1M solution can be prepared (pH approx 7). Pratically insoluble in organic solvents /Tetrahydrate/ · Insoluble in organic solvents
Stability: Stable in air.
pH: Between 6,5 and 7,5 (1 % solution)
Colour: white
Flammability (solid, gas): combustible
Vapour pressure: (2.99E-019mmHg(25℃))
Water solubility: (28 % w/w, @ 20 ℃)
Vapour density: 12.99
Relative density: 1.647 (@ 20 ℃)
n-Octanol/water partition coefficient (Kow): -10.42
Auto-ignition temperature: 292 ℃
Molecular weight: 374.268

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 58 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Processing aids not otherwise specified28
Stabilizing agent7
Chelating agent7
Preservative7
Soil amendments4
Flavouring and nutrient1
Fragrance1
Antioxidant1

2 other uses

Dye1
Biocide1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 0 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 1 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: CFR, Title 49, Section 173.240 according to