Ingredient Dictionary

CALCIUM PYROPHOSPHATE

Calcium diphosphate is a calcium phosphate.

Definition

Calcium diphosphate is a calcium phosphate. It contains a diphosphate(4-).

Source: PubChem

US FDA substance register · UNII X69NU20D19 · registered name CALCIUM PYROPHOSPHATE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Cares for the mouthORAL CAREProtects colour and scent from lightLIGHT STABILIZERScrubs physicallyABRASIVE

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Safety Assessment of Phosphoric Acid and Its Salts as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name リン酸（Ｃａ／セリウム）: 本品は、炭酸Ｃａ（＊）、ピロリン酸カルシウム及びセリウムの焼成物である。

Source: JCIA labelling names (Japan)

Names & identifiers

CALCIUM PYROPHOSPHATEINCI칼슘파이로포스페이트Korean label name (MFDS standard)Diphosphoric acid, calcium salt (1:2)SynonymCALCIUM CERIUM PHOSPHATESynonym

CAS No.chemical registry number: 7790-76-3
EC No.EU chemical inventory number: 232-221-5
DTXSIDUS EPA chemical ID: DTXSID50872512
DTXCIDUS EPA compound ID: DTXCID40820163

IUPAC: Dicalcium diphosphate
Molecular formula: Ca2O7P2
Molecular weight: 254.097 g/mol

Measured properties

Appearance: Dry Powder · A fine, white, odourless powder
Melting point: 1353 °C
Solubility: Insoluble in water. Soluble in dilute hydrochloric and nitric acids · Sol in dil hydrochloric and nitric acids, practically insol in water
Density: 3.09
pH: Between 5,5 and 7,0 (10 % suspension in water)
Colour: white
Melting/freezing point: 1353 ℃
Relative density: 3.09
Molecular weight: 254.10

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Abrasive3
Filler1
Flavouring and nutrient1
Stabilizing agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 4 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

Studies Indicate No Significant Irritation
skin corrosion: in vitro / ex vivo · Screening · EU Method B.46 (In Vitro Skin Irritation: Reconstructed Human Epidermis Model Test) according to OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method) according to
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) 2012 according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Ambiguous
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to EU method B.47 (Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to