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成分词典

成分词典

CALCIUM THIOGLYCOLATE

分子结构

定义

美国FDA 物质登记 · UNII J96129652N · 登记名称 CALCIUM THIOGLYCOLATE · 单一化学物质

来源: 美国FDA 物质识别码(UNII)

化妆品中的作用

软化并松解角质层KERATOLYTIC溶解毛发以去除DEPILATORY还原其他成分REDUCING

安全与法规参考

限用
韩国

来源: 韩国食药处 化妆品法规信息

阿根廷 · 巴西

  • Field of application and/or use : (a) Products for hair straightening or waving: 1. General use 2. Professional use (b) Depilatories (c) Other products for hair care which are removed after application
  • Maximum concentration permitted at final product : (a) 1. 8% ready to use pH 7 to 9.5 2. 11% ready to use pH 7 to 9.5 (b) 5% ready to use pH 7 to 12.7 (c) 2% .ready to use pH 7 to 9.5 The indicated percentages are calculated as thioglycolic acid
  • Other limitations and requirements : a, b and c) In the USAGE must obligatorily the following information recorded: - Avoid contact with eyes. - In case of contact with eyes, rinse immediately with plenty water and consult a doctor - and c) Wear suitable gloves
  • Use conditions and warnings that must appear on the label : a), b) and c) - Contains thioglycolic acid salts - Follow instructions - Keep out of reach of children - Only for professional use (where appropriate)

东盟

  • Field of application and/or use : (a) Hair waving or straightening products: 1. General use 2. Professional use (b) Depilatories (c) Other hair care products which are removed after application
  • Maximum authorised concentration in the finished cosmetic product : (a) 1. 8% ready for use at pH 7 – 9.5 2. 11% ready for use at pH 7- 9.5 (b) 5% ready for use at pH 7-12.7 (c) 2% ready for use at pH 7-9.5 For general use of hair waving or straightening products the maximum concentration for combination of Thioglycolic acid and thiolactic acid must not exceed 8% calculated as Thioglycolic Acid.
  • Other limitations and requirements : (a) (b) (c) The directions for use drawn up in the national or official language(s) must obligatorily incorporate the following sentences: • Avoid contact with eyes • In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice. • Wear suitable gloves (a) and (c) only.
  • Conditions of use and warning which must be printed on the labels : (a) • Contains thioglycolate • Follow the instructions • Keep out of reach of children. • For professional use only. (b) and (c) • Contains thioglycolate • Follow the instructions • Keep out of reach of children

加拿大

  • Conditions of Use by product type : (a) Eyelash curling products (b) Hair dyes, waving or straightening products (c) Hair dyes, waving or straightening products for professional use (d) Depilatory products
  • Maximum Concentration Permitted : ((a) 11% (as thioglycolic aci(d) with a pH less than or equal to 9.5 (b) 8% (as thioglycolic aci(d) with a pH less than or equal to 9.5 (c) 11% (as thioglycolic aci(d) with a pH less than or equal to 9.5 (d) 5% (as thioglycolic aci(d) with a pH less than or equal to 12.7
  • Warnings and Cautionary Statements: (to the effect of) : (a) "For professional use only.", "Avoid direct skin contact, wear suitable gloves.", "Avoid contact with eyes and, in the event of contact with eyes, rinse immediately with plenty of water and seek medical attention." (b)"Avoid direct skin contact, wear suitable gloves.", "Not for use in the area of the eye." (c) "For professional use only." "Avoid direct skin contact, wear suitable gloves.", "Not for use in the area of the eye." d) "Avoid contact with eyes and, in the event of contact with eyes, rinse immediately with plenty of water and seek medical attention."

中国

  • 最大配合量 : (a)

欧盟

  • Product Type, body parts : (a) Hair products (b) Depilatories (c) Hair rinse-off products (d) Products intended for eyelash waving
  • Maximum concentration in ready for use preparation : (a) 1) 8% 2) 11% (b) 5% (c) 2% (d) 11% The abovementioned percentages are calculated as thioglycollic acid
  • Other : (a) General use ready for use pH 7 to 9.5 Professional use ready for use pH 7 to 9.5 (b) ready for use pH 7 to 12.7 (c) ready for use pH 7 to 9.5 (d) ready for use pH 7 to 9,5
  • Wording of conditions of use and warnings : Condition of use: (a) (b) (c) Avoid contact with eyes In the event of contact with eyes, rinse immediately with plenty of water and seek medical advice (a) (c) (d) Wear suitable gloves Warnings to be printed on the label: (a) (b) (c) Contains thioglycolate Follow the instructions Keep out of reach of children (a) (d) For professional use only: Cotains thiglycolata, folow the instruction.

来源: 韩国食药处 化妆品法规信息

Restriction III/2a · Other restriction: ban substances that deplete the ozone layer

来源: 欧盟 CosIng 成分清单

Reviewed by CIR: Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid

来源: 美国CIR 安全性评估

详细资料——标示名称、识别编号、物性、试验记录、文献

官方标示名称和定义

日本化妆品工业联合会标示名称 チオグリコール酸Ca: 本品は、チオグリコール酸(*)のカルシウム塩であり、次の化学式で表される。

来源: 日本化妆品工业联合会标示名称

别名和识别信息

CALCIUM THIOGLYCOLATEINCI칼슘티오글라이콜레이트韩国标示名称(食药处标准名)Acetic acid, mercapto-, calcium salt (2:1)同义名チオグリコール酸Ca日本标示名称
CAS No.化学物质登记号
65208-41-5
CAS No.化学物质登记号
814-71-1
CAS No.化学物质登记号
5793-98-6
EC No.欧盟化学品目录编号
249-881-5
EC No.欧盟化学品目录编号
212-402-5
DTXSID美国EPA化学品编号
DTXSID6061151
DTXCID美国EPA化合物编号
DTXCID5048219
IUPAC
Calcium bis(sulfanylacetate)
分子式
C4H6CaO4S2
分子量
222.29 g/mol

实测物性

性状
固体
颜色
白色
pH
11-12
熔点/凝固点
220 ℃
初沸点和沸程
259.97 ℃
蒸气压
0.0159 ㎜Hg
溶解度
323150 ㎎/ℓ
正辛醇/水分配系数(Kow)
-2.490
分子量
222.30

这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。

来源: 韩国安全保健公团 安全数据表

产品实际使用的用途

这是向美国 EPA 申报含该成分的 15 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。

  • Depilatory (EPA)10
  • Reducing agent2
  • Pharmaceutical (EPA)2
  • Abrasive1

来源: 美国EPA CompTox

刺激与致敏试验记录

记录有皮肤试验 3 项、眼部试验 1 项。

归类为中等1 项

试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。

查看全部 4 项试验
  • Skin sensitisation - category 1
    Skin Sensitization · Screening
  • SkinSens1
    Skin Sensitization · QSAR Predicted
  • Skin irritation - category 2
    Skin Irritation · Screening
  • Eye irritation - category 2A
    Eye Irritation · Screening

来源: 美国EPA CompTox

相关文献

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