Octane-1,2-diol is an octanediol.
How much products actually contain
No product states its amount yet.
Of the products containing it, 3,122 list it before the 1% line and 3,520 after it (usually 1% or less).
Products using this ingredient
12 of 6,553 confirmed · likeliest to carry enough first · See all 6,553
BioSilk Silk TherapyHeat Enhancer UV Therapy Mist 150ml
ElizaveccaElizavecca Centella Asiatica Pure 200ml
AriulAriul All Green Feminine Wipes 40 Sheets
LAKALAKA Magic Lip Fixer
MustelaMustela Liniment
tartetarte smooth operator™ Amazonian clay finishing powder
M·A·CM·A·C Pigment - Tan
M·A·CM·A·C Pigment - Vanilla
VersedVersed Smooth Finish
Sigma BeautySigma Beauty Soft Focus Setting Powder
Sigma BeautySigma Beauty Soft Focus Setting Powder - INFL
Nails.INCNails.INC Cherry Scented Rapid Nail Polish Remover Pot
Definition
Octane-1,2-diol is an octanediol.
Source: PubChem
US FDA substance register · UNII 00YIU5438U · registered name CAPRYLYL GLYCOL · single chemical substance
Caprylyl Glycol is the diol that conforms to the formula
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Safety Assessment of 1,2-Glycols as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name カプリリルグリコール: 本品は、次の化学式で表されるジオールである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 1117-86-8
- EC No.EU chemical inventory number
- 214-254-7
- DTXSIDUS EPA chemical ID
- DTXSID9036646
- DTXCIDUS EPA compound ID
- DTXCID7016646
- IUPAC
- Octane-1,2-diol
- Molecular formula
- C8H18O2
- Molecular weight
- 146.23 g/mol
Measured properties
- Appearance
- Liquid · White solid, mp = 30-35 deg C, [CBW MSDS]
- Colour
- white
- Melting/freezing point
- 36 ℃
- Initial boiling point and range
- 243 ℃
- Flash point
- 138 ℃
- Vapour pressure
- 0.006 ㎜Hg (25℃)
- Water solubility
- 2933 ㎎/ℓ
- n-Octanol/water partition coefficient (Kow)
- 1.67
- Auto-ignition temperature
- 310 ℃
- Molecular weight
- 146.23
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 44 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner20
- Preservative15
- Humectant3
- Biocide2
- Intermediate1
- Deodorizer1
- Antioxidant1
- Fragrance1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
7 skin studies and 5 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 12 studies
- Category 6.3B (Category 3)
Skin Irritation · Read Across - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Guidelines for Toxicity Studies Required for Applications for Approval to Manufacture (Import) Drugs. Notification No. 24 of Pharmaceutical Affairs Bureau, MHW, Japan (Sep. 11, 1989), Attachment: Guidelines for Toxicity Studies of Drugs - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) of 2004 according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Guide to Quasi-drug and Cosmetic Regulations in Japan, Yakuji Nippo, Ltd., Feb. 2006 according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Method published in: Official French Gazette of 21 February 1982 according to - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) of 2002 - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) of 1981 - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) of 1987 according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) of 1992 according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Method published in: Official French Gazette of 10 July 1992 according to - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: s 1500, Federal Register, Vol. 38, No. 187, September 27th, 1973, p. 27019 according to - Severe Irritation
eye irritation: in vivo · Screening · EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) of 2004 according to
Source: US EPA CompTox dashboard
Related literature
- Effect of cosmetic films with ascorbic acid and hyaluronic acid on transepidermal water loss · 2021
- In vitro and in silico study on glucosylation of caprylyl glycol · 2024
- Allergic contact dermatitis to caprylyl glycol: A novel “para‐preservative” allergen · 2020
- Contact urticaria following the use of a cosmetic containing caprylyl glycol: A case report · 2019
- Application of a Multifunctional Additive in Cosmetic Preparations for Safe Preservation · 2019
Linked databases 21
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese