Captan can cause cancer according to The Environmental Protection Agency (EPA).
Definition
Captan can cause cancer according to The Environmental Protection Agency (EPA).
Source: PubChem
US FDA substance register · UNII EOL5G26Q9F · registered name Captan · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · Taiwan · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
Korea’s toxic-substance GHS classification: Danger · H400 (category 1) · H351 (category 2) · H317 (category 1) · +2 more
EU Cosmetics Regulation, Annex II (prohibited substances), entry 370
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
Restriction II/370
Source: EU CosIng ingredient list
Reviewed by CIR: Final Report on the Safety Assessment of Captan
CIR reviewed this ingredient and flagged its status as: CIR insufficient data ingredients - use not supported (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 133-06-2
- EC No.EU chemical inventory number
- 205-087-0
- DTXSIDUS EPA chemical ID
- DTXSID9020243
- DTXCIDUS EPA compound ID
- DTXCID90243
- IUPAC
- 2-[(Trichloromethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
- Molecular formula
- C9H8Cl3NO2S
- Molecular weight
- 300.58 g/mol
Measured properties
- Appearance
- solid
- Melting/freezing point
- 173~175 ℃ ((EU Method A.1, GLP))
- Initial boiling point and range
- 173 ℃
- Flash point
- 143 ℃
- Vapour pressure
- (2.01 Pa(calc.), ca. 50℃, EU Method A.4)
- Water solubility
- ca. 3.77 ㎎/ℓ ((25℃, pH=ca. 6.47)(EU Method A.6))
- Relative density
- ca. 1.65 (22 °C, EU Method A.3, GLP)
- n-Octanol/water partition coefficient (Kow)
- 2.8
- Decomposition temperature
- 178 ℃
- Molecular weight
- 300.59
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 88 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Biocide88
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
7 skin studies and 5 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 12 studies
- Skin Sens. 1
Skin Sensitization · Screening - Category 1
Skin Sensitization · Screening - Category 2
Skin Irritation · Screening - High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) - Skin Sens. 1
Skin Sensitization · Authoritative - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to - Eye Dam. 1
Eye Irritation · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Eye Dam. 1
Eye Irritation · Authoritative - Category 1
Eye Irritation · Screening - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Source: US EPA CompTox dashboard
Related literature
- Captan: Problems Associated with its Identification in Environmental Materials and Food Products. Potential Solutions · 2023
- Captan: Problems Associated with its Identification in Environmental Objects and Food Products. Ways of Solution · 2022
- Characterizing Local Acute Irritation Properties of Captan and Folpet with New Approach Methods · 2022
- An Evaluation of the Common Mechanism Approach to the Food Quality Protection Act: Captan and Four Related Fungicides, a Practical Example · 2000
- Exposure to captan in fruit growing. · 1998
Linked databases 25
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- Health Canada Cosmetic Ingredient Hotlist
- IARC carcinogen classification
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata
- Wikipedia · English · Japanese · Chinese