Chlorhexidine acetate is the acetate salt of chlorhexidine.
Definition
US FDA substance register · UNII 5908ZUF22Y · registered name CHLORHEXIDINE ACETATE · single chemical substance
Chlorhexidine acetate is the acetate salt of chlorhexidine. It is a disinfectant used for bacterial control in hospital, agricultural and domestic environments. It has a role as an antibacterial agent, an antiinfective agent, an antifungal agent and an antifouling biocide. It contains a chlorhexidine.
Source: PubChem
Chlorhexidine Diacetate is a salt of Chlorhexidine and acetic acid. It conforms generally to the formula:
Cosmetic roles
Safety & regulatory references
- Restricted
- China · South Korea
Source: MFDS (Korea) cosmetic regulatory information
Argentina · Brazil
- Maximum concentration permitted at final product : 0.3% (expressed as chlorhexidine)
ASEAN
- Maximum authorised concentration in the finished cosmetic product : 0.3% expressed as chlorhexidine
Taiwan
- 0.3%
European Union
- Maximum concentration in ready for use preparation : 0.3% (as chlorhexidine)
Source: MFDS (Korea) cosmetic regulatory information
Health Canada Cosmetic Ingredient Hotlist · restricted with conditions
Restriction V/42
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010
Reviewed by CIR: Note Regarding the Safety Assessment of Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, and Chlorhexidine Dihydrochloride
Reviewed by CIR: Final Report on the Safety Assessment of Chlorhexidine/Chlorhexidine Diacetate/Chlorhexidine Dihydrochloride/Chlorhexidine Digluconate
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 56-95-1
- EC No.EU chemical inventory number
- 200-302-4
- DTXSIDUS EPA chemical ID
- DTXSID7032345
- DTXCIDUS EPA compound ID
- DTXCID5012345
- IUPAC
- Acetic acid--N,N''''-hexane-1,6-diylbis[N'-(4-chlorophenyl)triimidodicarbonic diamide] (2/1)
- Molecular formula
- C26H38Cl2N10O4
- Molecular weight
- 625.56 g/mol
Measured properties
- Appearance
- solid
- Colour
- white
- Odour
- odourless
- pH
- 6.8 (in 1% solution)
- Melting/freezing point
- 158.7 ℃
- Initial boiling point and range
- 693.68 ℃
- Water solubility
- 19000 ㎎/ℓ (20°C)
- Vapour density
- 21.594753192958233
- Relative density
- 1.2
- n-Octanol/water partition coefficient (Kow)
- 4.85
- Molecular weight
- 625.6
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Biocide2
- Preservative1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- SkinSens1
Skin Sensitization · QSAR Predicted - Category 8.3A (Category 1)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Acanthamoeba Keratitis in a 5-Year-Old Boy Without a History of Contact Lens Usage · 2006
- Wound Dressings Based on Chitosans and Hyaluronic Acid for the Release of Chlorhexidine Diacetate in Skin Ulcer Therapy · 2007
- Effectiveness of chlorhexidine diacetate and povidone‐iodine in antiseptic preparation of the canine external ear canal prior to total ear canal ablation with bulla osteotomy procedure: A preliminary study · 2023
- Engineering a Titanium and Polycaprolactone Construct for a Biocompatible Interface Between the Body and Artificial Limb · 2009
- Final Report on the Safety Assessment of Chlorhexidine/Chlorhexidine Diacetate/Chlorhexidine Dihydrochloride/Chlorhexidine Digluconate · 1993
Linked databases 19
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Health Canada Cosmetic Ingredient Hotlist
- Korea Cosmetic Association ingredient dictionary
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata