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Ingredient Dictionary

CHLORHEXIDINE DIGLUCONATE

Chlorhexidine gluconate is a D-gluconate adduct and an organochlorine compound.

Molecular structure

How much products actually contain

No product states its amount yet.

Of the products containing it, 0 list it before the 1% line and 22 after it (usually 1% or less).

Products using this ingredient

12 of 22 confirmed · likeliest to carry enough first · See all 22

Definition

Chlorhexidine gluconate is a D-gluconate adduct and an organochlorine compound. It has a role as an antibacterial agent. It is functionally related to a chlorhexidine.

Source: PubChem

US FDA substance register · UNII MOR84MUD8E · registered name Chlorhexidine Gluconate · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Chlorhexidine Digluconate is a salt of Chlorhexidine and gluconic acid. It conforms generally to the formula:

Cosmetic roles

Stops microbes growing in the productPRESERVATIVECares for the mouthORAL CAREInhibits microbial growthANTIMICROBIAL

Safety & regulatory references

Restricted
China · South Korea

Source: MFDS (Korea) cosmetic regulatory information

Argentina · Brazil

  • Maximum concentration permitted at final product : 0.3% (expressed as chlorhexidine)

ASEAN

  • Maximum authorised concentration in the finished cosmetic product : 0.3% expressed as chlorhexidine

Taiwan

  • 0.3%

Japan

  • Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.050 g
  • Maximum amount per 100 g (Cosmetics that may be used for mucosa) : 0.050 g

European Union

  • Maximum concentration in ready for use preparation : 0.3% (as chlorhexidine)

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Health Canada Cosmetic Ingredient Hotlist · restricted with conditions

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction V/42 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Chlorhexidine/Chlorhexidine Diacetate/Chlorhexidine Dihydrochloride/Chlorhexidine Digluconate

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Note Regarding the Safety Assessment of Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, and Chlorhexidine Dihydrochloride

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name グルコン酸クロルヘキシジン: 本品は、グルコン酸（＊）とクロルヘキシジン（＊）の塩であり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

CHLORHEXIDINE DIGLUCONATEINCI클로헥시딘다이글루코네이트Korean label name (MFDS standard)D-Gluconic acid, compd. with N1,N14-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)Synonymグルコン酸クロルヘキシジンJapanese labelling name
CAS No.chemical registry number
18472-51-0
EC No.EU chemical inventory number
242-354-0
DTXSIDUS EPA chemical ID
DTXSID5034519
DTXCIDUS EPA compound ID
DTXCID3014519
IUPAC
N,N''''-Hexane-1,6-diylbis[N'-(4-chlorophenyl)triimidodicarbonic diamide]--D-gluconic acid (1/2)
Molecular formula
C34H54Cl2N10O14
Molecular weight
897.76 g/mol

Measured properties

Appearance
Liquid

Values measured on the substance itself, not a specification for a commercial raw material.

Source: PubChem

What products actually use it for

What the 10 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Preservative6
  • Biocide3
  • Fragrance1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 3 eye studies are on record.

Classed as low4

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies
  • Category 6.3A (Category 2)
    Skin Irritation · Read Across
  • Not likely to be sensitizing
    skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
  • Ambiguous
    skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
  • Severe Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
  • Category 6.4A (Category 2A)
    Eye Irritation · Read Across
  • Moderate or Mild Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to

Source: US EPA CompTox dashboard

Related literature

Linked databases 20

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