Ingredient Dictionary

CHLOROACETAMIDE

2-chloroacetamide is a monocarboxylic acid amide that is acetamide substituted by a chloro group at position 2.

Definition

2-chloroacetamide is a monocarboxylic acid amide that is acetamide substituted by a chloro group at position 2. It has a role as an antimicrobial cosmetic preservative, a fungicide, a herbicide and an antimicrobial agent. It is a primary carboxamide, a monocarboxylic acid amide, an organochlorine compound and a N-acylammonia.

Source: PubChem

US FDA substance register · UNII 2R97846T1L · registered name Chloroacetamide · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Chloroacetamide is the aliphatic amide that conforms to the formula:

Cosmetic roles

Stops microbes growing in the productPRESERVATIVE

Safety & regulatory references

Banned: ASEAN · Canada · European Union · Taiwan · United Kingdom
Restricted or banned: Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · Taiwan

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS) · MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1387

Source: EU prohibited substances (Annex II)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction II/1387 · SCCS opinion: Opinion on Chloroacetamide

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of Chloroacetamide

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

CHLOROACETAMIDEINCI클로로아세타마이드Korean label name (MFDS standard)Acetamide, 2-chloro-Synonym

CAS No.chemical registry number: 79-07-2
EC No.EU chemical inventory number: 201-174-2
DTXSIDUS EPA chemical ID: DTXSID9041570
DTXCIDUS EPA compound ID: DTXCID7021570

IUPAC: 2-Chloroacetamide
Molecular formula: C2H4ClNO
Molecular weight: 93.51 g/mol

Measured properties

Melting/freezing point: 120 ℃
Flash point: 170 ℃
Vapour pressure: 7 ㎩
Water solubility: 9 g/100㎖ (20℃)
Vapour density: 3.2
n-Octanol/water partition coefficient (Kow): -0.53
Decomposition temperature: 225 ℃
Molecular weight: 93.51

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Preservative2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

8 skin studies and 3 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 11 studies

Skin Sens. 1
Skin Sensitization · Authoritative
Sh
Skin Sensitization · Authoritative
Category 1
Skin Sensitization · Screening
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Skin sensitisation - category 1
Skin Sensitization · Screening
Category 2
Skin Irritation · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Category 2A
Eye Irritation · Screening
Eye irritation - category 2A
Eye Irritation · Screening
Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to