Chloroacetic acid is a chlorocarboxylic acid that is acetic acid carrying a 2-chloro substituent.
定义
Chloroacetic acid is a chlorocarboxylic acid that is acetic acid carrying a 2-chloro substituent. It has a role as an alkylating agent and a herbicide. It is a haloacetic acid and a chlorocarboxylic acid. It is functionally related to an acetic acid. It is a conjugate acid of a chloroacetate.
来源: PubChem
美国FDA 物质登记 · UNII 5GD84Y125G · 登记名称 Chloroacetic Acid · 单一化学物质
化妆品中的作用
安全与法规参考
韩国有毒物质 GHS 分类: 危险 · H311 (第3类) · H400 (第1类) · H301 (第3类) · 另有 2 项
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 クロロ酢酸: 本品は、次の化学式で表される有機化合物である。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
- CAS No.化学物质登记号
- 79-11-8
- EC No.欧盟化学品目录编号
- 201-178-4
- DTXSID美国EPA化学品编号
- DTXSID4020901
- DTXCID美国EPA化合物编号
- DTXCID20901
- IUPAC
- Chloroacetic acid
- 分子式
- C2H3ClO2
- 分子量
- 94.49 g/mol
实测物性
- 性状
- Chloroacetic acid, solid is a colorless to light-brown crystalline material. It is soluble in water and sinks in water. Combustible. It is transported as a molten liquid and therefore can cause thermal burns. It is toxic by ingestion, skin absorption and inhalation of dust. It is corrosive to metals and tissue. · Chloroacetic acid, solution is a colorless solution of the white crystalline solid. The acid concentration can be up to 80%. It is toxic by inhalation, ingestion and skin contact. It is corrosive to metals and tissue. It is used as an herbicide, preservative and bacteriostat.
- 气味
- Strong vinegar-like odor
- 沸点
- 372 °F at 760 mmHg (EPA, 1998) · 189.1 °C
- 熔点
- 145 °F (EPA, 1998) · 50-63 °C
- 溶解性
- greater than or equal to 100 mg/mL at 68 °F (NTP, 1992) · In water, 8.58X10+5 mg/L at 25 °C
- 密度
- 1.4043 at 104 °F (EPA, 1998) - Denser than water, will sink · 1.328 (USCG, 1999) - Denser than water, will sink
- 稳定性
- Stable under recommended storage conditions.
- 解离常数
- pKa = 2.87
- pH
- 1.93
- 熔点/凝固点
- 63 ℃
- 初沸点和沸程
- 189 ℃
- 闪点
- 126 ℃(c.c.)
- 蒸发速率
- 1
- 燃烧或爆炸范围上限/下限
- 8 / - %
- 蒸气压
- 0.016 ㎜Hg(20℃)
- 溶解度
- 1000 g/ℓ(20℃)
- 蒸气密度
- 3.26
- 比重
- 1.37 (20℃)
- 正辛醇/水分配系数（Kow）
- 0.49
- 自燃温度
- &, gt, 500 ℃ (&, 1 011.9 - &, lt, 1 022 hPa)
- 分解温度
- 715.9 ℃(kJ/mol)
- 黏度
- 1.29 cP(100℃)
- 分子量
- 94.5
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 7 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Biocide2
- Intermediate2
- Pharmaceutical (EPA)1
- Surfactant (surface active agent)1
- Monomers1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 5 项、眼部试验 3 项。
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 8 项试验
- Skin Corr. 1B
Skin Irritation · Authoritative - Classification not possible
Skin Sensitization · Screening - Skin corrosion/irritation - Category 1
Skin Irritation · Screening - Category 1A
Skin Irritation · Screening - Category 8.2C (Category 1C)
Skin Irritation · Read Across - Category 1
Eye Irritation · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: FDA guideline: federal register 38, no. 187, 27-09-1973, p 27019 according to
来源: 美国EPA CompTox
相关文献
- Chloroacetic acids induce skin aging via cGAS/STING/NF-κB pathway in HaCaT cells, human explants and rats. · 2025
- The GC MS Study of One Ayurvedic Formulation, Navayasa Churnam · 2024
- Case report: Occupational poisoning incident from a leak of chloroacetyl chloride in Jinan, Shandong, China · 2023
- chloroacetic acid · 2020
- Clinical observation on 10 cases of skin burns caused by chloroacetic acid · 2009