Chlorobutanol is a tertiary alcohol.
- Korean limit
- 0.50%
Definition
Chlorobutanol is a tertiary alcohol.
Source: PubChem
US FDA substance register · UNII HM4YQM8WRC · registered name Chlorobutanol · single chemical substance
Chlorobutanol is a halogenated alcohol that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Allowed preservative
- United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Japan Standards for Cosmetics · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
Argentina · Brazil
- Maximum concentration permitted at final product : 0.5%
- Other limitations and requirements : Banned in sprayable systems (such as aerosols and sprays)
- Use conditions and warnings that must appear on the label : It contains chlorobutanol
ASEAN
- Maximum authorised concentration in the finished cosmetic product : 0.5%
- Other limitations and requirements : Prohibited in aerosol dispensers (sprays)
- Conditions of use and warning which must be printed on the labels : - Contains chlorobutanol
Taiwan
- Maximum concentration : 0.5%
- 0.5%
Japan
- Maximum amount per 100 g(Maximum amount of ingredient per 100 g) : 0.10(0.10 g)
China
- Maximum concentration : 0.5%
South Korea
- Maximum concentration : 0.50%
European Union
- Maximum concentration in ready for use preparation : 0.5%
- Other : Not to be used in aerosol dispensers (sprays)
- Wording of conditions of use and warnings : Contains Chlorobutanol
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex V (allowed preservatives), entry 11 · maximum concentration 0.5%
Restriction V/11
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name クロロブタノール: 本品は、次の化学式で表されるハロゲン化アルコールである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 57-15-8
- EC No.EU chemical inventory number
- 200-317-6
- DTXSIDUS EPA chemical ID
- DTXSID1041217
- DTXCIDUS EPA compound ID
- DTXCID9021217
- IUPAC
- 1,1,1-Trichloro-2-methylpropan-2-ol
- Molecular formula
- C4H7Cl3O
- Molecular weight
- 177.45 g/mol
Measured properties
- Appearance
- Colorless to white solid, [Merck Index] Crystalline solid, [MSDSonline] · NEEDLES (WATER+1)
- Odour
- Camphor odor · Characteristic odor
- Boiling point
- 167 · 167 °C
- Melting point
- 99 · 97 °C
- Solubility
- INSOL IN COLD WATER, SOL IN HOT WATER · 1 G IN 125 ML WATER, SOL IN VOLATILE OILS
- Stability
- EMPLOYED IN SOLN @ PH 5 OR LOWER, WHICH IS STABLE FOR AT LEAST MANY MO
- Colour
- white
- Melting/freezing point
- 97 ℃
- Initial boiling point and range
- 167 ℃
- Flammability (solid, gas)
- combustible
- Vapour pressure
- 0.833 ㎜Hg (@ 25 ℃, est.)
- Water solubility
- 8000 ㎎/ℓ (@ 20 ℃)
- Vapour density
- 6.13
- n-Octanol/water partition coefficient (Kow)
- 2.03
- Molecular weight
- 177.46
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Preservative2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Category 6.3B (Category 3)
Skin Irritation · Read Across - SkinIrr2
Skin Irritation · QSAR Predicted - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Toxicity of ingredients in artificial tears and ophthalmic drugs in a cell attachment and spreading test · 1991
- Microbial contamination of cosmetics and the pharmaceutical products, and their preservation strategies: A comprehensive review · 2023
- A Rare Case Report of Conjunctival Cyst. · 2015
- [Effects of pre-instilled mydriatics on the intraocular concentration and anti-inflammatory action of topical 0.1% pranoprofen (3)--study on permeability factor]. · 1992
- Cytotoxic effects of benzalkonium chloride and chlorobutanol on human corneal epithelial cells in vitro. · 1989
Linked databases 27
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU allowed preservatives (Annex V)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- Japan Standards for Cosmetics
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese