Ingredient Dictionary

CHLOROFORM

Chloroform can cause cancer and developmental toxicity according to an independent committee of scientific and health experts.

Definition

Chloroform can cause cancer and developmental toxicity according to an independent committee of scientific and health experts.

Source: PubChem

US FDA substance register · UNII 7V31YC746X · registered name Chloroform · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Base that dissolves other ingredientsSOLVENT

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · Canada · China · European Union · Japan · South Korea · Taiwan · United Kingdom · United States

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · Japan Standards for Cosmetics · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS) · US eCFR cosmetics regulations · US FDA prohibited and restricted ingredients

Korea’s toxic-substance GHS classification: Danger · H372 (category 1) · H331 (category 3) · H315 (category 2) · +5 more

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 366

Source: EU prohibited substances (Annex II)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction II/366 · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

CHLOROFORMINCI클로로폼Korean label name (MFDS standard)Methane, trichloro-Synonym

CAS No.chemical registry number: 67-66-3
EC No.EU chemical inventory number: 200-663-8
DTXSIDUS EPA chemical ID: DTXSID1020306
DTXCIDUS EPA compound ID: DTXCID10306

IUPAC: Trichloromethane
Molecular formula: CHCl3
Molecular weight: 119.37 g/mol

Measured properties

Appearance: Chloroform appears as a clear colorless liquid with a characteristic odor. Denser (12.3 lb / gal) than water and slightly soluble in water. Hence sinks in water. Nonflammable under most conditions, but burns under extreme conditions. May cause illness by inhalation, skin absorption or ingestion. Used as a solvent, to make other chemicals, as a fumigant. · Liquid
Odour: Pleasant, etheric, nonirritating · Pleasant odor
Boiling point: 143 °F at 760 mmHg (EPA, 1998) · 61.12 °C
Melting point: -82.3 °F (EPA, 1998) · -63.47 °C
Solubility: less than 1 mg/mL at 66 °F (NTP, 1992) · In water, 7.95X10+3 mg/L at 25 °C
Density: 1.4832 at 68 °F (EPA, 1998) - Denser than water, will sink · 1.4788 g/cu cm at 25 °C
Odour threshold: 3.3 ppm
Melting/freezing point: -63.5 ℃
Initial boiling point and range: 61.23 ℃(1013 hPa)
Evaporation rate: 11.6
Vapour pressure: 211 hPa(20℃)
Water solubility: 8.7 g/ℓ
Vapour density: 4.12
Relative density: 1.4788 (g/cu cm at 25℃)
n-Octanol/water partition coefficient (Kow): 1.97 (log Pow, 25℃)
Auto-ignition temperature: 600 ℃(1013 hPa)
Viscosity: 0.563 cP
Molecular weight: 119.378

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 7 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent2
Intermediate2
Processing aids not otherwise specified1
Chemical reaction regulator1
Degradant/impurity (EPA)1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

9 skin studies and 5 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 14 studies

Classification not possible
Skin Sensitization · Screening
Category 2
Skin Irritation · Screening
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to EU Method B.6 (Skin Sensitisation)
Skin Irrit. 2
Skin Irritation · Authoritative
Skin irritation - category 2
Skin Irritation · Screening
Skin corrosion/irritation - Category 2
Skin Irritation · Screening
Category 6.3A (Category 2)
Skin Irritation · Read Across
Skin Irrit. 2
Skin Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Category 1
Eye Irritation · Screening
Eye Irrit. 2
Eye Irritation · Authoritative
Eye irritation - category 2A
Eye Irritation · Screening
Serious eye damage/eye irritation - Category 2
Eye Irritation · Screening