2-benzyl-4-chlorophenol is a diarylmethane.
- Korean limit
- 0.05%
Definition
Chlorophene is the halogenated phenolic compound that conforms to the formula:
2-benzyl-4-chlorophenol is a diarylmethane.
Source: PubChem
US FDA substance register · UNII 7560BB0BO3 · registered name CLOROPHENE · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- ASEAN · European Union · United Kingdom
- Restricted or banned
- Argentina · ASEAN · Brazil · China · European Union
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)
Taiwan
- Maximum concentration : 0.2%
South Korea
- Maximum concentration : 0.05%
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex II (prohibited substances), entry 1602
Restriction II/1602
Source: EU CosIng ingredient list
Reviewed by CIR: Safety Assessment of Dichlorophene and Chlorophene
CIR reviewed this ingredient and flagged its status as: Insufficient data ingredients with no uses reported to FDA's Voluntary Cosmetic Registration Program (VCRP) (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 120-32-1
- EC No.EU chemical inventory number
- 204-385-8
- DTXSIDUS EPA chemical ID
- DTXSID5020154
- DTXCIDUS EPA compound ID
- DTXCID30154
- IUPAC
- 2-Benzyl-4-chlorophenol
- Molecular formula
- C13H11ClO
- Molecular weight
- 218.68 g/mol
Measured properties
- Appearance
- Ortho-benzyl-para-chlorophenol appears as white to light tan or pink flakes or white crystals. Insoluble in water. Slight phenolic odor. (NTP, 1992) · White to light tan or pink solid, [Hawley]
- Odour
- White to light tan or pink flakes
- Boiling point
- 320 to 324 °F at 3.5 mmHg (NTP, 1992) · 160-162 °C at 3.5 mm Hg
- Melting point
- 119.3 °F (NTP, 1992) · 48.5 °C
- Solubility
- less than 1 mg/mL at 61 °F (NTP, 1992) · Highly sol in alcohol and other org solvents
- Density
- 1.22 (NTP, 1992) - Denser than water, will sink · 1.185 at 58 °C
- Melting/freezing point
- 49 ℃
- Initial boiling point and range
- 160~162 ℃
- Flash point
- 159 ℃
- Upper/lower flammability or explosive limits
- 12 / 2.0 %
- Vapour pressure
- 0.0000506 ㎜Hg (at 25C(est.)
- Water solubility
- 149 ㎎/ℓ (at 25C)
- Vapour density
- 2.1 ()
- Relative density
- 1.186-1.190 ( at 55 C)
- n-Octanol/water partition coefficient (Kow)
- 4.18 ((est.))
- Auto-ignition temperature
- 490 ℃
- Molecular weight
- 218.69
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Biocide4
- Preservative1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 6 studies
- SkinIrr2
Skin Irritation · QSAR Predicted - Skin Irrit. 2
Skin Irritation · Authoritative - SkinSens1
Skin Sensitization · QSAR Predicted - Skin Sens. 1
Skin Sensitization · Authoritative - Eye Dam. 1
Eye Irritation · Authoritative - Category 8.3A (Category 1)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- Safety Assessment of Dichlorophene and Chlorophene1 · 2004
- Development of the active ingredient composition of hand antiseptics in Germany from 2004 to 2022 with special consideration of ethanol as active agent · 2025
- Inverse gas chromatographic characterization of halloysite-carbon composites as adsorbents for skin disinfectants from water solutions · 2024
- Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An in Silico and in Vitro Study · 2020
- Safety assessment of dichlorophene and chlorophene. · 2004
Linked databases 27
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata
- Wikipedia · Chinese