Ingredient Dictionary

CHOLECALCIFEROL

Calciol is a hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group.

How much products actually contain

No product states its amount yet.

Of the products containing it, 5 list it before the 1% line and 0 after it (usually 1% or less).

Products using this ingredient

5 of 5 confirmed · likeliest to carry enough first

Definition

Calciol is a hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone. It has a role as a geroprotector and a human metabolite. It is a steroid hormone, a secondary alcohol, a seco-cholestane, a hydroxy seco-steroid and a member of D3 vitamins.

Source: PubChem

US FDA substance register · UNII 1C6V77QF41 · registered name Cholecalciferol · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Cares for the mouthORAL CARESkin conditioning not covered aboveSKIN CONDITIONING - MISCELLANEOUS

Safety & regulatory references

Restricted or banned: Argentina · ASEAN · Brazil · China · European Union · South Korea · Taiwan

Source: MFDS (Korea) cosmetic regulatory information

Canada

Conditions of Use by product type : Average daily absorption must be equal to or less than 25 µg per day.

Source: MFDS (Korea) cosmetic regulatory information

Korea’s toxic-substance GHS classification: Danger · H310 (category 2) · H372 (category 1) · H330 (category 2) · +1 more

Source: Korea toxic substances GHS register (NIER)

Restriction II/335

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name コレカルシフェロール: 本品は、ビタミンＤ３であり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

CHOLECALCIFEROLINCI콜레칼시페롤Korean label name (MFDS standard)Cyclohexanol, 3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1S,3Z)-SynonymコレカルシフェロールJapanese labelling name

CAS No.chemical registry number: 67-97-0
EC No.EU chemical inventory number: 200-673-2
DTXSIDUS EPA chemical ID: DTXSID6026294
DTXCIDUS EPA compound ID: DTXCID306294

IUPAC: (3S,5Z,7E)-9,10-Secocholesta-5,7,10-trien-3-ol
Molecular formula: C27H44O
Molecular weight: 384.648 g/mol

Measured properties

Appearance: Vitamin d3 appears as fine colorless crystals. Water insoluble. (NTP, 1992) · Colorless or white odorless solid, [HSDB] White crystals, [Sigma-Aldrich MSDS]
Odour: ODORLESS · odourless
Melting point: 183 to 185 °F (NTP, 1992) · 84.5 °C
Solubility: Insoluble (NTP, 1992) · Insoluble
Stability: Oxidized and inactivated by moist air within few days. · Affected by light and air.
Colour: white
Melting/freezing point: 84~85 ℃
Vapour pressure: 0.0000000024 ㎜Hg(25 °C)
Water solubility: 0.000013 ㎎/ℓ(at 25°C)
n-Octanol/water partition coefficient (Kow): 10.24
Molecular weight: 384.6436

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 19 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Pharmaceutical (EPA)9
Softener and conditioner5
Biocide4
Flavouring and nutrient1

Source: US EPA CompTox dashboard