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Ingredient Dictionary

CHOLESTEROL

Cholesterol is a cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.

Clinical evidence
  • Dryness C
  • Skin barrier D
Amount studies used
formula ratio
When
morning and evening
Irritation
low

Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.

Molecular structure

How much products actually contain

1 products state the amountmedian 0.0025%

  • under 0.01% 1
  • 0.01–0.1% 0
  • 0.1–1% 0
  • 1% or more 0

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

Of the products containing it, 296 list it before the 1% line and 751 after it (usually 1% or less).

Clinical evidence grade by skin concern

C
uncontrolled or multi-ingredient studies
D
lab work or a record only
1 references

Products using this ingredient

12 of 1,045 confirmed · likeliest to carry enough first · See all 1,045

Definition

Cholesterol is a cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group. It has a role as a mouse metabolite, a human metabolite, a Daphnia galeata metabolite and an algal metabolite. It is a C27-steroid, a 3beta-hydroxy-Delta(5)-steroid, a 3beta-sterol and a cholestanoid.

Source: PubChem

US FDA substance register · UNII 97C5T2UQ7J · registered name Cholesterol · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONINGAdjusts thicknessVISCOSITY CONTROLLINGMakes skin soft and smoothSKIN CONDITIONING - EMOLLIENTMixes and holds oil and water togetherSURFACTANT - EMULSIFYINGProtects colour and scent from lightLIGHT STABILIZER

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2004/2005

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Re-Review Summary of Cholesterol as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of Cholesterol

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name コレステロール: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

CHOLESTEROLINCI콜레스테롤Korean label name (MFDS standard)Cholest-5-en-3-ol, (3.beta.)-SynonymコレステロールJapanese labelling name
CAS No.chemical registry number
57-88-5
EC No.EU chemical inventory number
200-353-2
DTXSIDUS EPA chemical ID
DTXSID3022401
DTXCIDUS EPA compound ID
DTXCID402401
IUPAC
Cholest-5-en-3beta-ol
Molecular formula
C27H46O
Molecular weight
386.664 g/mol

Measured properties

Appearance
White or faintly yellow solid, Nearly odorless, [HSDB] Beige solid, [Sigma-Aldrich MSDS] · Solid
Odour
Almost odorless
Boiling point
360 °C · 360 °C (decomposes)
Melting point
148.5 °C · MP: 145.5 °C (the melt becomes clear at 180 °C), optical rotation (25 °C/D) = -13.7 deg (c = 0.9 in chloroform) /Benzoate/
Solubility
0.095 mg/L (at 30 °C) · Moderately soluble in hot alcohol, soluble in benzene, oils, fats and aq solns of bile salts
Density
1.067 @ 20 °C/4 °C · Pearly leaflets or plates from dilute alcohol, becomes anhydrous at 70-80 °C, density 1.03, practically insoluble in water (about 0.2 mg/100 ml H2O), slightly soluble in alcohol (1.29% w/w at 20 °C), more soluble in hot alcohol (100 g of saturated 96% alcoholic solution contains 28 g at 80 °C), one gram dissolves in 2.8 ml ether, in 4.5 ml chloroform, in 1.5 ml pyridine. Also soluble in benzene pe
Colour
white
Melting/freezing point
141 ℃
Flash point
250 ℃
Vapour pressure
1.1E-7 ㎩ (25℃)
Water solubility
30.7 ug/L (20℃, pH: 7.5)
Vapour density
1.05 g/㎤
Relative density
1.067 (20/4℃)
n-Octanol/water partition coefficient (Kow)
&amp, gt, 6.5 (log Pow)
Decomposition temperature
&amp, gt, 200 ℃
Molecular weight
386.65

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 49 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Softener and conditioner30
  • Stabilizing agent6
  • Emulsifier5
  • Processing aids not otherwise specified2
  • Fragrance2
  • Viscosity modifier2
  • Thickening agent1
  • Pharmaceutical (EPA)1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 1 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies
  • Not likely to be sensitizing
    skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation)
  • SkinIrr2
    Skin Irritation · QSAR Predicted
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · other guideline: JMAFF guidelines (2000); including the most recent partial revisions. according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EPA OPPTS 870.2400 (Acute Eye Irritation) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to

Source: US EPA CompTox dashboard

Related literature

Linked databases 23

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