Ingredient Dictionary

CHOLINE CHLORIDE

Choline chloride is a quaternary ammonium salt with choline cation and chloride anion.

Definition

Choline chloride is a quaternary ammonium salt with choline cation and chloride anion. It has a role as an animal growth promotant. It is a chloride salt and a quaternary ammonium salt. It contains a choline.

Source: PubChem

US FDA substance register · UNII 45I14D8O27 · registered name Choline chloride · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Draws in and holds moistureHUMECTANTKeeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 168

Source: EU prohibited substances (Annex II)

Restriction II/168

Source: EU CosIng ingredient list

Reviewed by CIR: Safety Assessment of Trimoniums as used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name 塩化コリン: 本品は、次の化学式で表される４級アンモニウム塩である。

Source: JCIA labelling names (Japan)

Names & identifiers

CHOLINE CHLORIDEINCI콜린클로라이드Korean label name (MFDS standard)Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1)Synonym塩化コリンJapanese labelling name

CAS No.chemical registry number: 67-48-1
EC No.EU chemical inventory number: 200-655-4
DTXSIDUS EPA chemical ID: DTXSID4020325
DTXCIDUS EPA compound ID: DTXCID20325

IUPAC: 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride
Molecular formula: C5H14ClNO
Molecular weight: 139.62 g/mol

Measured properties

Appearance: Choline chloride appears as white crystals. Practically neutral aqueous solution. (NTP, 1992) · Dry Powder, Liquid
Melting point: 577 to 581 °F (Decomposes) (NTP, 1992) · 305 °C (decomposes)
Solubility: Very soluble (NTP, 1992) · Very sol in water and alcohol
Stability: Keep tightly closed.
pH: 4.7 (10% SOLN IN WATER) · 4.7
Colour: white
Flammability (solid, gas): combustible
Vapour pressure: 0 ㎩ (@ 25 ℃)
Vapour density: 4.82
Relative density: 1.1
n-Octanol/water partition coefficient (Kow): -3.77 (at 25 ℃)
Auto-ignition temperature: 330 ℃
Decomposition temperature: 305 ℃
Viscosity: 26.2 cP (at 20 ℃)
Molecular weight: 139.63

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 16 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Stabilizing agent4
Soil amendments4
Processing aids not otherwise specified2
Flavouring and nutrient1
Humectant1
Anti-static agent1
Surfactant (surface active agent)1
Softener and conditioner1

1 other uses

Solvent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 1 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 2 studies

Category 6.3B (Category 3)
Skin Irritation · Read Across
Category 6.4A (Category 2A)
Eye Irritation · Read Across