Azophloxine is an organic sodium salt that is the disodium salt of 5-acetamido-4-hydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid.
Definition
US FDA substance register · UNII 3365R6427R · registered name ACID RED 1 · single chemical substance
Azophloxine is an organic sodium salt that is the disodium salt of 5-acetamido-4-hydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid. It has a role as a histological dye. It contains a 5-acetamido-4-hydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonate.
Source: PubChem
CI 18050 is classed chemically as a monoazo colour. It conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Restricted
- ASEAN · China · Taiwan
- Allowed colourant
- ASEAN · Taiwan · United States
Source: MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · Taiwan FDA cosmetic ingredients · US FDA prohibited and restricted ingredients
Argentina · Brazil
- Field of application and/or use : Dye Substances allowed exclusively in products that do not have contact with mucosa in regular and predictable use conditions.
European Union
- Product Type, body parts : Not to be used in products applied on mucous membranes
- Other : Purity criteria as set out in Commission Directive 95/45/EC (E 128)
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex IV (allowed colourants), entry 38 · maximum concentration Not to be used in products applied on mucous membranes
Source: EU allowed colourants (Annex IV)
Restriction IV/38
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 3734-67-6
- EC No.EU chemical inventory number
- 223-098-9
- DTXSIDUS EPA chemical ID
- DTXSID9044663
- DTXCIDUS EPA compound ID
- DTXCID7024663
- IUPAC
- Disodium 5-acetamido-4-hydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonate
- Molecular formula
- C18H13N3Na2O8S2
- Molecular weight
- 509.41 g/mol
Measured properties
- Appearance
- solid
- Odour
- odourless
- Water solubility
- (22%, 25℃)
- Vapour density
- 17.6
- Relative density
- 0.38-0.43
- Molecular weight
- 511.46
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 9 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye7
- Pigment1
- Fragrance1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- SkinSens1
Skin Sensitization · QSAR Predicted - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: as below according to - Ambiguous
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: as below
Source: US EPA CompTox dashboard
Linked databases 18
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- China inventory of existing ingredients (IECIC)
- EU allowed colourants (Annex IV)
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3 4
- PubChem
- Taiwan FDA cosmetic ingredients
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA prohibited and restricted ingredients
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata 2