What is this ingredient?

미국 FDA 물질 등록 · UNII O8RYS681QI · 등록명 PIGMENT YELLOW 13 · 단일 화학물질

All ingredients

Ingredient Dictionary

CI 21100

CI 21100 is classed chemically as a disazo colour.

Definition

US FDA substance register · UNII O8RYS681QI · registered name PIGMENT YELLOW 13 · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

CI 21100 is classed chemically as a disazo colour. It conforms to the formula:

Cosmetic roles

Dyes hairHAIR DYEINGAdds colourCOLORANT

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · European Union · United Kingdom
Restricted or banned: Argentina · ASEAN · Brazil · China · European Union · Taiwan
Allowed colourant: ASEAN · Taiwan

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS) · Taiwan FDA cosmetic ingredients

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex IV (allowed colourants), entry 47 · maximum concentration Rinse-off products

Source: EU allowed colourants (Annex IV)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1351

Source: EU prohibited substances (Annex II)

Restriction II/1351 (Pigment Yellow 13; CI 21100: when used as a substance in hair dye products)

Source: EU CosIng ingredient list

Restriction IV/47 (CI 21100) II/1351 (Pigment Yellow 13; CI 21100: when used as a substance in hair dye products)

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

CI 21100INCI피그먼트황색13호Korean label name (MFDS standard)Butanamide, 2,2'-[[3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl]bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxo-SynonymPIGMENT YELLOW 13Synonym

CAS No.chemical registry number: 5102-83-0
EC No.EU chemical inventory number: 225-822-9
DTXSIDUS EPA chemical ID: DTXSID0029268
DTXCIDUS EPA compound ID: DTXCID30809902

IUPAC: 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)di(hydrazin-2-yl-1-ylidene)]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide]
Molecular formula: C36H34Cl2N6O4
Molecular weight: 685.61 g/mol

Measured properties

Appearance: solid
Odour: odourless
Initial boiling point and range: 320 ℃
Flash point: 500 ℃
Vapour pressure: (4.62E-023mmHg 25℃(est.))
Vapour density: 23.7
Relative density: 1.2
n-Octanol/water partition coefficient (Kow): (&amp, gt, 6)
Auto-ignition temperature: (&amp, gt, 100℃)
Molecular weight: 685.598960

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 22 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Pigment17
Dye5

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

8 skin studies and 7 eye studies are on record.

Classed as low15

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 15 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: method given in the "Hazardous Substances Regulations" under the U.S. Federal Hazardous Substances Labelling Act Sect. 191.11 (February 1965) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO). according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: FDA-guidelines according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: FDA guideline (Fed. Reg. Vol. 37, No. 38, 1972) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: FDA guideline (Fed. Reg., Vol. 37, No. 38, 1972) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: procedure set out in the "Hazardous Substances Regulations" under the U.S.A. Federal Hazardous Substances Labelling Act Sect. 191.12 (February 1965), conducted with slight modification. according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO) according to