What is this ingredient?

미국 FDA 물질 등록 · UNII 67HO7X7FV3 · 등록명 PIGMENT YELLOW 83 · 단일 화학물질

All ingredients

Ingredient Dictionary

CI 21108

CI 21108 is classed chemically as a disazo colour.

How much products actually contain

No product states its amount yet.

Of the products containing it, 3 list it before the 1% line and 0 after it (usually 1% or less).

Products using this ingredient

3 of 3 confirmed · likeliest to carry enough first

Definition

US FDA substance register · UNII 67HO7X7FV3 · registered name PIGMENT YELLOW 83 · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

CI 21108 is classed chemically as a disazo colour. It conforms to the formula:

Cosmetic roles

Adds colourCOLORANT

Safety & regulatory references

Restricted: China · Taiwan
Allowed colourant: Taiwan

Source: MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · Taiwan FDA cosmetic ingredients

Argentina · Brazil

Field of application and/or use : Dye Substances allowed exclusively in products that have short time of skin and hair contact.
Other limitations and requirements : Maximum dimethylbenzidine concentration:

ASEAN

Field of application : Colouring agents allowed exclusively in cosmetic products intended to come into contact only briefly with the skin.
Other limitations and requirements : Maximum 3,3’-dimethylbenzidine concentration in the colouring agent: 5 ppm

European Union

Product Type, body parts : Rinse-off products
Other : Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex IV (allowed colourants), entry 48 · maximum concentration Rinse-off products

Source: EU allowed colourants (Annex IV)

Restriction IV/48

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

CI 21108INCIButanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxo-Synonym

CAS No.chemical registry number: 5567-15-7
EC No.EU chemical inventory number: 226-939-8
DTXSIDUS EPA chemical ID: DTXSID1021453
DTXCIDUS EPA compound ID: DTXCID90809908

IUPAC: 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(diazene-2,1-diyl)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide]
Molecular formula: C36H32Cl4N6O8
Molecular weight: 818.49 g/mol

Measured properties

Appearance: Liquid, Wet Solid, Other Solid, Dry Powder, CBI · Yellow powder, [Trust Chem MSDS]
Odour: odourless
Melting/freezing point: &amp, gt, 320 ℃
Relative density: 1.37 (20℃)
n-Octanol/water partition coefficient (Kow): 7.54
Viscosity: (1.37g/㎤ at 20 ℃)
Molecular weight: 818.5

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 51 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Pigment29
Dye15
Degradant/impurity (EPA)4
Processing aids not otherwise specified3

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

8 skin studies and 8 eye studies are on record.

Classed as low15

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 16 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: method given in the "Hazardous Substances Regulations" under the U.S. Federal Hazardous Substances Labelling Act Sect. 191.11 (February 1965) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO). according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: FDA-guidelines according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: procedure set out in the "Hazardous Substances Regulations" under the U.S.A. Federal Hazardous Substances Labelling Act Sect. 191.12 (February 1965), conducted with slight modification. according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: FDA guideline (Fed. Reg., Vol. 37, No. 38, 1972) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: FDA guideline (Fed. Reg. Vol. 37, No. 38, 1972) according to