CI 21108 is classed chemically as a disazo colour.
产品中实际含有多少
暂无产品标示该成分含量。
含该成分的产品中，3 款将其列在 1% 线之前，0 款列在之后（通常不超过 1%）。
含有此成分的产品
已确认 3 款中的 3 款 · 按含量充足程度排序
定义
美国FDA 物质登记 · UNII 67HO7X7FV3 · 登记名称 PIGMENT YELLOW 83 · 单一化学物质
CI 21108 is classed chemically as a disazo colour. It conforms to the formula:
化妆品中的作用
着色COLORANT
安全与法规参考
- 限用
- 中国
来源: 韩国食药处 化妆品法规信息
阿根廷 · 巴西
- Field of application and/or use : Dye Substances allowed exclusively in products that have short time of skin and hair contact.
- Other limitations and requirements : Maximum dimethylbenzidine concentration:
东盟
- Field of application : Colouring agents allowed exclusively in cosmetic products intended to come into contact only briefly with the skin.
- Other limitations and requirements : Maximum 3,3’-dimethylbenzidine concentration in the colouring agent: 5 ppm
台湾
- 2. 未列載於此表規定範圍之成分，於歐盟、美國及日本三國家地區，任何其中一個國家地區官方已公告（以生效日為準）其使用基準者，得參照其基準規定准予使用(但下表CI 11380 等十九項成分不適用)，惟於申請查驗登記時，應同時檢附該等地區之准許使用基準證明文件。
- 用途 : 色素
欧盟
- Product Type, body parts : Rinse-off products
- Other : Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
来源: 韩国食药处 化妆品法规信息
未列入韩国有毒物质 GHS 分类 · 现有化学物质
欧盟化妆品法规 附录IV（准用着色剂） 第48项 · 最高浓度 Rinse-off products
来源: 欧盟准用着色剂（附录IV）
Restriction IV/48
来源: 欧盟 CosIng 成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
CI 21108INCIButanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxo-同义名
- CAS No.化学物质登记号
- 5567-15-7
- EC No.欧盟化学品目录编号
- 226-939-8
- DTXSID美国EPA化学品编号
- DTXSID1021453
- DTXCID美国EPA化合物编号
- DTXCID90809908
- IUPAC
- 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(diazene-2,1-diyl)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide]
- 分子式
- C36H32Cl4N6O8
- 分子量
- 818.49 g/mol
实测物性
- 性状
- Liquid, Wet Solid, Other Solid, Dry Powder, CBI · Yellow powder, [Trust Chem MSDS]
- 气味
- 无臭
- 熔点/凝固点
- &, gt, 320 ℃
- 比重
- 1.37 (20℃)
- 正辛醇/水分配系数（Kow）
- 7.54
- 黏度
- (1.37g/㎤ at 20 ℃)
- 分子量
- 818.5
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 51 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Pigment29
- Dye15
- Degradant/impurity (EPA)4
- Processing aids not otherwise specified3
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 8 项、眼部试验 8 项。
归类为低15 项
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 16 项试验
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: method given in the "Hazardous Substances Regulations" under the U.S. Federal Hazardous Substances Labelling Act Sect. 191.11 (February 1965) according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO). according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation) - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to EU Method B.6 (Skin Sensitisation) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: FDA-guidelines according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: procedure set out in the "Hazardous Substances Regulations" under the U.S.A. Federal Hazardous Substances Labelling Act Sect. 191.12 (February 1965), conducted with slight modification. according to - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: FDA guideline (Fed. Reg., Vol. 37, No. 38, 1972) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: FDA guideline (Fed. Reg. Vol. 37, No. 38, 1972) according to
来源: 美国EPA CompTox