Ingredient Dictionary

CI 74100

Phthalocyanine is a tetrapyrrole fundamental parent that consists of four isoindole-type units, with the connecting carbon atoms in the macrocycle replaced by nitrogen.

Definition

Phthalocyanine is a tetrapyrrole fundamental parent that consists of four isoindole-type units, with the connecting carbon atoms in the macrocycle replaced by nitrogen. It is a tetrapyrrole fundamental parent and a member of phthalocyanines.

Source: PubChem

US FDA substance register · UNII V5PUF4VLGY · registered name PIGMENT BLUE 16 · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

CI 74100 is classed chemically as a phthalocyanine colour. It conforms to the formula:

Cosmetic roles

Adds colourCOLORANT

Safety & regulatory references

Restricted: ASEAN · China · Taiwan
Allowed colourant: ASEAN · Taiwan · United Kingdom

Source: MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

Field of application and/or use : Dye Substances allowed exclusively in products that have short time of skin and hair contact.

European Union

Product Type, body parts : Rinse-off products

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex IV (allowed colourants), entry 104 · maximum concentration Rinse-off products

Source: EU allowed colourants (Annex IV)

Restriction IV/104

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

CI 74100INCI29H,31H-PhthalocyanineSynonym

CAS No.chemical registry number: 574-93-6
EC No.EU chemical inventory number: 209-378-3
DTXSIDUS EPA chemical ID: DTXSID9025906
DTXCIDUS EPA compound ID: DTXCID705906

IUPAC: Phthalocyanine
Molecular formula: C32H18N8
Molecular weight: 514.552 g/mol

Measured properties

Appearance: solid
Melting/freezing point: 210 ℃
Initial boiling point and range: &amp, lt, 550 ℃
Vapour pressure: (3E-29mmHg 25℃)
Vapour density: 17.74
n-Octanol/water partition coefficient (Kow): 3.57
Molecular weight: 514.55

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 15 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Pigment9
Dye5
Surface modifier1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 4 eye studies are on record.

Classed as low6

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 10 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Code of Federal Regulations, Title 16, Section 1500.42 according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Code of Federal Regulations, Title 16, Section 1500, 42 according to
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Code of Federal Regulations, Title 16, Section 1500.41 according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Code of Federal Regulations, Title 16, Section 1500.42 according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Code of Federal Regulations, Title 16, Section 1500, 41 according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to