Isotretinoin can cause developmental toxicity according to an independent committee of scientific and health experts.
Definition
Isotretinoin can cause developmental toxicity according to an independent committee of scientific and health experts.
Source: PubChem
US FDA substance register · UNII EH28UP18IF · registered name Isotretinoin · single chemical substance
cis-Retinoic Acid is the organic compound that conforms to the formula
Cosmetic roles
Safety & regulatory references
Korea’s toxic-substance GHS classification: Danger · H360 (category 1) · H315 (category 2)
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
Restriction II/375
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 4759-48-2
- EC No.EU chemical inventory number
- 225-296-0
- DTXSIDUS EPA chemical ID
- DTXSID4023177
- DTXCIDUS EPA compound ID
- DTXCID403177
- IUPAC
- (13cis)-Retinoic acid
- Molecular formula
- C20H28O2
- Molecular weight
- 300.442 g/mol
Measured properties
- Odour
- odourless
- Melting/freezing point
- 174~175 ℃
- Initial boiling point and range
- 462.8 ℃(at 760 ㎜Hg)
- Flash point
- 350.6 ℃
- Vapour pressure
- 1.02E-7 ㎜Hg (25℃)
- Water solubility
- 0.126 ㎎/ℓ (25℃)
- Relative density
- 1.011g/cm3
- n-Octanol/water partition coefficient (Kow)
- 5.6
- Molecular weight
- 300.44
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
Irritation and sensitisation studies
2 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 3 studies
- Category 6.3A (Category 2)
Skin Irritation · Read Across - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
- A comparison of dapsone with 13‐cis retinoic acid in the treatment of nodular cystic acne · 1988
- Effects of dietary retinyl palmitate or 13-cis-retinoic acid on the promotion of tumors in mouse skin. · 1987
- 13-cis-Retinoic Acid: It’s Therapeutic Implications and Adverse Effects · 2021
- 9-cis Retinoic Acid is the ALDH1A1 Product that Stimulates Melanogenesis · 2013
- Kinetics of Plasma and Tissue Distribution of 9-cis-Retinoic Acid in Rat · 2000
Linked databases 15
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- Health Canada Cosmetic Ingredient Hotlist
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese