1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3.
- Korean limit
- 0.5%
How much products actually contain
No product states its amount yet.
Of the products containing it, 16 list it before the 1% line and 27 after it (usually 1% or less).
Products using this ingredient
12 of 43 confirmed · likeliest to carry enough first · See all 43
KIOSKINKIOSKIN Anti-Dandruff Shampoo
RutonWomen's Scalp Alpha Ergen Anti-Hair Loss Tonic 150ml
ElastineBiotin Clinic 10000 Shampoo
JUDIMERHairlook Shampoo Mini
Labo HDandruff Clinic Shampoo 750ml
Labo HDandruff Clinic Shampoo 333ml
ROUND LABROUND LAB Pine Calming Cica Shampoo 400ml
Dr.BangGiWonLAB Anti-Hair-Loss Shampoo
Dr.BangGiWonLAB Anti-Hair-Loss Shampoo
TRIMAYGreen Capsule Apple Vinegar Scalp Scaler
RutonWomen's Scalp Alpha Ergen Anti-Hair Loss Shampoo 500ml
ElastineBiotin Clinic 10000 Conditioner
Definition
US FDA substance register · UNII 9N42CW7I54 · registered name CLIMBAZOLE · single chemical substance
1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a hemiaminal ether, a ketone, a member of imidazoles, an aromatic ether and a member of monochlorobenzenes.
Source: PubChem
Climbazole is the heterocyclic organic compound that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Restricted
- South Korea · United Kingdom
- Allowed preservative
- United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)
Argentina · Brazil
- Field of application and/or use : Agente anticaspa em xampus com enxágue.
- Maximum concentration permitted at final product : 2%
- Maximum concentration permitted at final product : 0.5%
ASEAN
- Field of application and/or use : (a) Rinse-off Anti-Dandruff Shampoo (b) Rinse-off Anti-Dandruff Conditioners
- Maximum authorised concentration in the finished cosmetic product : (a) 2.0% (b) 0.5%
- Other limitations and requirements : For (a) and (b): For purposes other than inhibiting the development of micro‐organisms in the product. This purpose has to be apparent from the presentation of the product. For use as a preservative, see Annex VI, No. 32
- Field of application and/or use : (a) Hair lotions (b) Face creams (c) Rinse‐off shampoo (d) Rinse-off hair conditioner
- Maximum authorised concentration in the finished cosmetic product : (a) 0.2% (b) 0.2% (c) 0.5% (d) 0.5%
Taiwan · China
- Maximum concentration : 0.5%
European Union
- Product Type, body parts : Rinse-off anti-dandruff shampoo
- Maximum concentration in ready for use preparation : 2,0 %
- Other : For purposes other than inhibiting the development of micro-organisms in the product. This purpose has to be apparent from the presentation of the product.
- Maximum concentration in ready for use preparation : 0.5%
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex V (allowed preservatives), entry 32 · maximum concentration (a) 0,2 % (b) 0,2 % (c) 0,2 % (d) 0,5 % · applies to (a) Hair lotions (b) Face creams (c) Foot care products (d) Rinse-off shampoo
Restriction V/32 and III/310 · SCCS opinion: Addendum to the Opinion SCCS/1506/13 on Climbazole; ADDENDUM to the scientific Opinions on Climbazole (P64) ref. SCCS/1506/13 and SCCS/1590/17; Opinion concerning Restrictions on Materials listed in annex VI of Directive 76/768/EEC on Cosmetic Products; Opinion on Climbazole
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name クリンバゾール: 本品は、次の化学式で表される複素環式化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 38083-17-9
- EC No.EU chemical inventory number
- 253-775-4
- DTXSIDUS EPA chemical ID
- DTXSID6046555
- DTXCIDUS EPA compound ID
- DTXCID4026555
- IUPAC
- 1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one
- Molecular formula
- C15H17ClN2O2
- Molecular weight
- 292.76 g/mol
Measured properties
- Appearance
- solid
- Water solubility
- 5.5 ppm (in water)
- n-Octanol/water partition coefficient (Kow)
- 3.76
- Molecular weight
- 292.76
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 9 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Anti-dandruff (EPA)3
- Preservative3
- Biocide3
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
4 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 7 studies
- Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: former version of EU Method B.6 (Skin Sensitisation): EEC 79/831, Appendix V, Part B, 4.1.7. Skin Sensitization - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: Buehler, 1965 - Ambiguous
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation) - Studies Indicate No Significant Irritation
skin corrosion: in vitro / ex vivo · Screening · other guideline: According to Human Skin Model Test EU-Method B.46 adopted 23. July 2009 according to - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: INVITTOX Protocol No. 47: HET-CAM Test according to - Ambiguous
eye irritation: in vivo · Screening · other guideline: The investigations were carried out in compliance with the recommendations of the Department of Health, Education and Welfare (Hazardous Substances, Test for Eye Irritants, Federal Register 37, 8534, 1972). according to - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 437: "Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants", 2009 according to
Source: US EPA CompTox dashboard
Related literature
- A validated LC-MS/MS method for the quantification of climbazole metabolites in human urine. · 2021
- Percutaneous Absorption of climbazole: In Vitro Data from Human Skin. · 2025
- Human urinary excretion kinetics of the antimycotic climbazole: Biomonitoring of two new metabolites after oral and dermal dosage. · 2024
- Analysis of transcriptional response in zebrafish eleutheroembryos exposed to climbazole: Signaling pathways and potential biomarkers · 2019
- Climbazole boosts activity of retinoids in skin · 2017
Linked databases 27
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU allowed preservatives (Annex V)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU SCCS safety opinions 2 3 4
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- PubChem
- Taiwan FDA cosmetic ingredients 2
- Taiwan FDA cosmetic regulations
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS) 2
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English